ReviewNature nanotechnology2021
Comprehensive framework for human health risk assessment of nanopesticides.
Review in Nature nanotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of nanocarriers used in medicine and beyond - definition and categorization framework.Journal of nanobiotechnology · 2025Pooled it
- Engineered nano-pesticides: a multifaceted strategy for sustainable crop protection and enhanced food security in the era of climate change.Plant signaling & behavior · 2026Review
- Particle Size Measurement of Organic Nanocarriers: A Case Study Using Polyacrylate-Based Polymer Nanocarriers.Small science · 2026Article
- Rational polymorph design to enhance isoxaflutole herbicidal performance and enable dosage reduction.Pest management science · 2026Article
- Nitric Oxide and Hydrogen Sulfide Crosstalk in Plants: Redox Regulation, Stress Adaptation, and Emerging Applications.International journal of molecular sciences · 2026Review
- The use of new approach methodologies (high-throughput transcriptomics) to study nanoagrochemicals: mechanisms of toxicity of a commercial copper oxychloride to soil model invertebrates (Enchytraeus crypticus).Archives of toxicology · 2026Article
- Plasmonic Supercavitation Enables Nanoparticle Photo-Ejection Across Air/Water Interface.Small science · 2026Article
- Oxidative stress and osmolyte induction caused by a Thiobencarb nano-emulsion in the freshwater alga Chlorella vulgaris.Ecotoxicology (London, England) · 2026Article
- Nanopesticides by Design: A Review of Delivery Platforms, Environmental Fate, and Standards for Safe and Sustainable Crop Protection.Molecules (Basel, Switzerland) · 2026Review
- BioCNT-TLS engineered systemic mobile resistome for sustainable crop protection.Frontiers in plant science · 2026Review
- Effect of fluazifop-P-butyl herbicide on growth, pigment, and ultrastructure of Auxenochlorella pyrenoidosa and Raphidocelis subcapitata.Environmental analysis, health and toxicology · 2025Article
- A unimolecule nanopesticide delivery system applied in field scale for enhanced pest control.Nature communications · 2025Article
- Nanoscale reference and test materials for the validation of characterization methods for engineered nanomaterials - current state, limitations, and needs.Analytical and bioanalytical chemistry · 2025Review
- Nanobased Natural Polymers as a Carrier System for Glyphosate: An Interesting Approach Aimed at Sustainable Agriculture.Journal of agricultural and food chemistry · 2025Article
- Harnessing pycnidia-forming fungi for eco-friendly nanoparticle production, applications, and limitations.Frontiers in microbiology · 2025Review
- Nanoemulsions Based Therapeutic Strategies: Enhancing Targeted Drug Delivery against Breast Cancer Cells.International journal of nanomedicine · 2025Review
- Comprehensive risk-benefit assessment of chemicals: A case study on glyphosate.Toxicology reports · 2024Article
- Engineered nanomaterials reduce metal(loid) accumulation and enhance staple food production for sustainable agriculture.Nature food · 2024Article
- Bacterial Pesticides: Mechanism of Action, Possibility of Food Contamination, and Residue Analysis Using MS.Journal of pesticide science · 2024Article
- Making the Complicated Simple: A Minimizing Carrier Strategy on Innovative Nanopesticides.Nano-micro letters · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanopesticides are not only in an advanced state of research and development but have started to appear on the market. Industry and regulatory agencies need a consolidated and comprehensive framework and guidance for human health risk assessments. In this perspective we develop such a comprehensive framework by exploring two case studies from relevant product types: an active ingredient delivered with a nanocarrier system, and a nanoparticle as an active ingredient. For a nanocarrier system, three entities are tracked during the assessment: the nanocarrier-active ingredient complex, the empty nanocarrier remaining after the complete release of the active ingredient, and the released active ingredient. For the nanoparticle of pure active ingredient, only two entities are relevant: the nanoparticle and the released ions. We suggest important adaptations of the existing pesticide framework to determine the relevant nanopesticide entities and their concentrations for toxicity testing. Depending on the nature of the nanopesticides, additional data requirements, such as those pertaining to durability in biological media and potential for crossing biological barriers, have also been identified. Overall, our framework suggests a tiered approach for human health risk assessment, which is applicable for a range of nanopesticide products to support regulators and industry in making informed decisions on nanopesticide submissions. Brief summaries of suitable methods including references to existing standards (if available) have been included together with an analysis of current knowledge gaps. Our study is an important step towards a harmonized approach accepted by regulatory agencies for assessing nanopesticides.
Indexed as
Identifiers
34518657What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.