ArticleCommunications biology2021
Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- The Omnicausal Model Reveals the Highly Polyfactorial Nature of Complex Diseases.Genetic epidemiology · 2026Article
- Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions.Communications medicine · 2026Article
- Integration of latent factor analysis into multivariable Mendelian randomization.European journal of epidemiology · 2026Article
- Multi-omics characterization of type 2 diabetes associated genetic variation.medRxiv : the preprint server for health sciences · 2024Article
- Multivariate genetic architecture reveals testosterone-driven sexual antagonism in contemporary humans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Breaking down causes, consequences, and mediating effects of telomere length variation on human health.Genome biology · 2024Article
- Article
- An augmented Mendelian randomization approach provides causality of brain imaging features on complex traits in a single biobank-scale dataset.PLoS genetics · 2023Article
- Sparse dimensionality reduction approaches in Mendelian randomisation with highly correlated exposures.eLife · 2023Article
- Using genetic association data to guide drug discovery and development: Review of methods and applications.American journal of human genetics · 2023Review
- Fetal genome predicted birth weight and polycystic ovary syndrome in later life: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Polygenic Risk Score and Risk Factors for Preeclampsia and Gestational Hypertension.Journal of personalized medicine · 2022Article
- Polygenic Risk Score and Risk Factors for Gestational Diabetes.Journal of personalized medicine · 2022Article
- Polynomial Mendelian randomization reveals non-linear causal effects for obesity-related traits.HGG advances · 2022Article
- Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots.Nature communications · 2022Article
- Molecular Imaging of Central Dopamine in Obesity: A Qualitative Review across Substrates and Radiotracers.Brain sciences · 2022Review
- Multitrait GWAS to connect disease variants and biological mechanisms.PLoS genetics · 2021Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 5 countries.
Funding
Abstract
Obesity is a major risk factor for a wide range of cardiometabolic diseases, however the impact of specific aspects of body morphology remains poorly understood. We combined the GWAS summary statistics of fourteen anthropometric traits from UK Biobank through principal component analysis to reveal four major independent axes: body size, adiposity, predisposition to abdominal fat deposition, and lean mass. Mendelian randomization analysis showed that although body size and adiposity both contribute to the consequences of BMI, many of their effects are distinct, such as body size increasing the risk of cardiac arrhythmia (b = 0.06, p = 4.2 ∗ 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.