Evidence map›Paper›PMID 34518583›Full record

ArticleScientific reports2021

Interrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and function.

Sokratis Stoumpos, Alastair Rankin, Pauline Hall Barrientos, Kenneth Mangion, Ellon McGregor, Peter C Thomson, Karen Stevenson, Paul Welsh, Ram Kasthuri, David B Kingsmore and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sokratis StoumposInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. sokratis.stoumpos@ggc.scot.nhs.uk.
Alastair RankinInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Pauline Hall BarrientosDepartment of Radiology, Queen Elizabeth University Hospital, Glasgow, UK.
Kenneth MangionInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Ellon McGregorRenal & Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Peter C ThomsonRenal & Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Karen StevensonRenal & Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Paul WelshInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Ram KasthuriDepartment of Radiology, Queen Elizabeth University Hospital, Glasgow, UK.
David B KingsmoreRenal & Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Giles RoditiDepartment of Radiology, Queen Elizabeth University Hospital, Glasgow, UK.
Patrick B MarkInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Queen Elizabeth University Hospital · GBUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arteriovenous fistula (AVF) is the preferred type of vascular access for maintenance haemodialysis but it may contribute to maladaptive cardiovascular remodelling. We studied the effect of AVF creation on cardiac structure and function in patients with chronic kidney disease (CKD). In this prospective cohort study patients with CKD listed for first AVF creation underwent cardiac magnetic resonance (CMR) imaging at baseline and at 6 weeks. All participants had ultrasound measurements of fistula blood flow at 6 weeks. The primary outcome was the change in left ventricular (LV) mass. Secondary outcomes included changes in LV volumes, LV ejection fraction, cardiac output, LV global longitudinal strain and N-terminal-pro B-type natriuretic peptide (NT-proBNP). A total of 55 participants were enrolled, of whom 40 (mean age 59 years) had AVF creation and completed both scans. On the second CMR scan, a mean increase of 7.4 g (95% CI 1.1-13.7, p = 0.02) was observed in LV mass. Significant increases in LV end-diastolic volumes (p = 0.04) and cardiac output (p = 0.02) were also seen after AVF creation. No significant changes were observed in LV end-systolic volumes, LV ejection fraction, NT-proBNP and LV global longitudinal strain. In participants with fistula blood flows ≥ 600 mL/min (n = 22) the mean increase in LV mass was 15.5 g (95% CI 7.3-23.8) compared with a small decrease of 2.5 g (95% CI - 10.6 to 5.6) in participants with blood flows < 600 mL/min (n = 18). Creation of AVF for haemodialysis resulted in a significant increase of LV myocardial mass within weeks after surgery, which was proportional to the fistula flow.

Indexed as

HemodynamicsAgedArteriovenous Shunt, SurgicalCardiac OutputCardiomegalyDisease ManagementEchocardiographyFemaleHeart DiseasesHeart Function TestsHumansKidney Failure, ChronicMagnetic Resonance ImagingMaleMiddle AgedPrognosis

Identifiers

PMID34518583
PMCPMC8437985
OpenAlexW3173645670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.