Evidence map›Paper›PMID 34518567›Full record

ArticleScientific reports2021

Functional versus morphological assessment of vascular age in patients with coronary heart disease.

Tino Yurdadogan, Carolin Malsch, Kornelia Kotseva, David Wood, Rainer Leyh, Georg Ertl, Wolfgang Karmann, Lara Müller-Scholden, Caroline Morbach, Margret Breunig and 5 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Vascular Age: A narrative review of assessment methods, clinical applications, and future directions.International journal of cardiology. Cardiovascular risk and prevention · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Tino YurdadoganComprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany. yurdadogan_t@ukw.de.
Carolin MalschInstitute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
Kornelia KotsevaNational Institute for Prevention and Cardiovascular Health, National University of Ireland, Galway, Ireland.
David WoodDepartment of Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
Rainer LeyhDepartment of Cardiothoracic and Thoracic Vascular Surgery, University Hospital Würzburg, Würzburg, Germany.
Georg ErtlComprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany.
Wolfgang KarmannDepartment of Medicine, Klinik Kitzinger Land, Kitzingen, Germany.
Lara Müller-ScholdenComprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany.
Caroline MorbachComprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany.
Margret BreunigComprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany.
Martin WagnerComprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany.
Götz GelbrichInstitute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Peter U HeuschmannInstitute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
Stefan StörkComprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany.
Universitätsklinikum Würzburg · DEUniversity of Würzburg · DEImperial College London · GBOllscoil na Gaillimhe – University of Galway · IEUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Communicating cardiovascular risk based on individual vascular age (VA) is a well acknowledged concept in patient education and disease prevention. VA may be derived functionally, e.g. by measurement of pulse wave velocity (PWV), or morphologically, e.g. by assessment of carotid intima-media thickness (cIMT). The purpose of this study was to investigate whether both approaches produce similar results. Within the context of the German subset of the EUROASPIRE IV survey, 501 patients with coronary heart disease underwent (a) oscillometric PWV measurement at the aortic, carotid-femoral and brachial-ankle site (PWVao, PWVcf, PWVba) and derivation of the aortic augmentation index (AIao); (b) bilateral cIMT assessment by high-resolution ultrasound at three sites (common, bulb, internal). Respective VA was calculated using published equations. According to VA derived from PWV, most patients exhibited values below chronological age indicating a counterintuitive healthier-than-anticipated vascular status: for VA

Indexed as

AgedAgingBlood VesselsCarotid Intima-Media ThicknessCoronary DiseaseFemaleHumansLinear ModelsMaleMiddle AgedPulse Wave Analysis

Identifiers

PMID34518567
PMCPMC8437950
OpenAlexW3200016313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.