ArticleNature communications2021
Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 128 citations in OpenAlex.
- Transcranial photoacoustic imaging of indocyanine green J-aggregates reveals cerebral signal changes in lipopolysaccharide-induced systemic inflammation.Photoacoustics · 2026Article
- Membrane-Bound Multimodal Plasmonic Transducers for Noninvasive, In Situ Monitoring and Control of CAR T Cells Against Heterogeneous Solid Tumors.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Harnessing Rare-Earth Materials as Exogenous Contrast Agents for Enhanced Photoacoustic Imaging.Chemical & biomedical imaging · 2026Review
- Lipid Bilayer-Confined J-Aggregation Transduces Cell Membrane Mechanics into Photoacoustic Signals.Journal of the American Chemical Society · 2026Article
- Versatile Co-Engineering of Immunogenic Cell Death-Primed Dead Tumor Cell Bodies With Tumor-Activated MnOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nanomaterials for In Vivo Photoacoustic Sensing: Emerging Strategies and Future Outlook.ACS sensors · 2026Review
- Contrasting temporal dynamics of fluorescence and photoacoustic signals from Cetuximab-IRDye800 conjugate in EGFR-overexpressing tumors.Science advances · 2026Article
- Directional conjugation of monoclonal antibodies to nanoparticles using metal-free click chemistry.Nature protocols · 2026Review
- MMP-Activated Liposomal Nanoplatform Co-loaded with Kaempferol and ICG for Targeted Imaging and Therapy of Abdominal Aortic Aneurysm.ACS applied materials & interfaces · 2026Article
- Lipid-stabilized ICG nanoaggregates for the photodisruption of vitreous opacities.Materials today. Bio · 2026Article
- Amplified Light Absorption with Nanomaterials for Enhanced Photoacoustic Imaging in Biomedical Research: A Review.Bioengineering (Basel, Switzerland) · 2026Review
- Conjugated oligoelectrolytes overcome cancer drug resistance by dual-mode lysosomal membrane disruption.Cancer drug resistance (Alhambra, Calif.) · 2026Article
- Potential of photoacoustic imaging for assessing tumor perfusion in intraocular tumors and high-resolution choroidal microvascular imaging: from technical advances to clinical translation.Frontiers in oncology · 2026Review
- Liposomal J-Aggregates of Indocyanine Green as a Multifunctional Contrast Agent for Photoacoustic Imaging and Photothermal Therapy.Nanotheranostics · 2026Article
- A multimodal approach to assess a liposomal carrier's biodistribution, stability, and clearance.Photoacoustics · 2025Article
- Improving vascular retention of indocyanine green forJournal of biomedical optics · 2025Article
- Targeted Delivery of Chlorin-e6-Loaded Carbon Nanotube-Based Nanobiocomposite to Cancer Stem Cells for Enhanced Photodynamic Therapy.Pharmaceutics · 2025Article
- Visualizing plant salt stress with a NaCl-responsive fluorescent probe.Nature protocols · 2025Review
- High-Throughput Microfluidic Production of Ultrasmall Lecithin Nanoliposomes for High-Efficacy Transdermal Delivery and Skin-Aging Treatment.Biomedicines · 2025Article
- Recent Advances in Indocyanine Green-Based Probes for Second Near-Infrared Fluorescence Imaging and Therapy.Research (Washington, D.C.) · 2025Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Photoacoustic (PA) imaging is a functional and molecular imaging technique capable of high sensitivity and spatiotemporal resolution at depth. Widespread use of PA imaging, however, is limited by currently available contrast agents, which either lack PA-signal-generation ability for deep imaging or their absorbance spectra overlap with hemoglobin, reducing sensitivity. Here we report on a PA contrast agent based on targeted liposomes loaded with J-aggregated indocyanine green (ICG) dye (i.e., PAtrace) that we synthesized, bioconjugated, and characterized to addresses these limitations. We then validated PAtrace in phantom, in vitro, and in vivo PA imaging environments for both spectral unmixing accuracy and targeting efficacy in a folate receptor alpha-positive ovarian cancer model. These study results show that PAtrace concurrently provides significantly improved contrast-agent quantification/sensitivity and SO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.