ReviewCold Spring Harbor perspectives in biology2022
Positional Information and Stem Cells Combine to Result in Planarian Regeneration.
Review in Cold Spring Harbor perspectives in biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- A flexible repertoire of wound closure strategies precedes whole-body regeneration.Nature communications · 2026Article
- Lack of specificity of planarian progenitor responses to injury in regeneration.bioRxiv : the preprint server for biology · 2026Article
- Whole-body single-cell atlas of an adult vertebrate in homeostasis and regeneration.bioRxiv : the preprint server for biology · 2026Article
- Retention and Distribution of Dopamine-Dependent Reward Memory in Regenerating Planaria.Biomolecules · 2026Article
- Enhanced cell contact and planarian tissue extract increase DNA replication and viability for neoblast cultivation.iScience · 2026Article
- The Sensory Basis of Planarian Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Emergent stable tissue shapes from the regulatory feedback between morphogens and cell growth.Journal of theoretical biology · 2026Article
- Article
- egal-1 and microtubules promote regeneration polarity in planarians.Development (Cambridge, England) · 2025Article
- Article
- Emergent Stable Tissue Shapes from the Regulatory Feedback between Morphogens and Cell Growth.bioRxiv : the preprint server for biology · 2025Article
- Reduced adult stem cell fate specification led to eye reduction in cave planarians.Nature communications · 2025Article
- Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance.Nature communications · 2024Article
- Schild Analysis of the Interaction between Parthenolide and Cocaine Suggests an Allosteric Relationship for Their Effects on Planarian Motility.Biomolecules · 2024Article
- Hallmarks of regeneration.Cell stem cell · 2024Review
- Mechanistic regulation of planarian shape during growth and degrowth.Development (Cambridge, England) · 2024Article
- A transcription factor atlas of stem cell fate in planarians.Cell reports · 2024Article
- The Ancient Origin and Function of Germline Cysts.Results and problems in cell differentiation · 2024Article
- LIM-HD transcription factors control axial patterning and specify distinct neuronal and intestinal cell identities in planarians.Open biology · 2023Article
- Fate specification is spatially intermingled across planarian stem cells.Nature communications · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The capacity for regeneration is broad in the animal kingdom. Planarians are flatworms that can regenerate any missing body part and their regenerative powers have combined with ease of experimentation to make them a classic regeneration model for more than a century. Pluripotent stem cells called neoblasts generate missing planarian tissues. Fate specification happens in the neoblasts, and this can occur in response to regeneration instructions in the form of positional information. Fate specification can lead to differentiating cells in single steps rather than requiring a long lineage hierarchy. Planarians display constitutive expression of positional information from muscle cells, which is required for patterned maintenance of tissues in tissue turnover. Amputation leads to the rapid resetting of positional information in a process triggered by wound signaling and the resetting of positional information is required for regeneration. These findings suggest a model for planarian regeneration in which adult positional information resets after injury to regulate stem cells to bring about the replacement of missing parts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.