Evidence map›Paper›PMID 34518340›Full record

ReviewCold Spring Harbor perspectives in biology2022

Axon Regeneration: A Subcellular Extension in Multiple Dimensions.

Carla C Winter, Zhigang He, Anne Jacobi

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carla C WinterF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Zhigang HeF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Anne JacobiF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

Funding

SOCS3 and optic nerve regenerationR01EY021526 · NEI · BOSTON CHILDREN'S HOSPITAL · PI HE, ZHIGANG · 2011 to 2020
$4.1M
CRSIPR screening for novel regulators of retinal ganglion cell survival and axonal regenerationR01EY030204 · NEI · BOSTON CHILDREN'S HOSPITAL · PI HE, ZHIGANG, SANES, JOSHUA R · 2019 to 2023
$2.7M
Promoting axon regeneration and functional recovery after SCIR01NS096294 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI HE, ZHIGANG · 2016 to 2020
$1.9M
TissueCyte 1600FC Whole Mount Tissue ScannerS10OD026866 · OD · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2019 to 2019
$612k
NEI NIH HHS R01 EY021526NEI NIH HHS R01 EY030204NIH HHS S10 OD026866NINDS NIH HHS R01 NS096294
6 · The paper itself

Abstract

Axons are a unique cellular structure that allows for the communication between neurons. Axon damage compromises neuronal communications and often leads to functional deficits. Thus, developing strategies that promote effective axon regeneration for functional restoration is highly desirable. One fruitful approach is to dissect the regenerative mechanisms used by some types of neurons in both mammalian and nonmammalian systems that exhibit spontaneous regenerative capacity. Additionally, numerous efforts have been devoted to deciphering the barriers that prevent successful axon regeneration in the most regeneration-refractory system-the adult mammalian central nervous system. As a result, several regeneration-promoting strategies have been developed, but significant limitations remain. This review is aimed to summarize historic progression and current understanding of this exciting yet incomplete endeavor.

Indexed as

AxonsNerve RegenerationAnimalsCentral Nervous SystemMammalsNeurons

Identifiers

PMID34518340
PMCPMC8886981

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.