Evidence map›Paper›PMID 34518221›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

A strong nonequilibrium bound for sorting of cross-linkers on growing biopolymers.

Yuqing Qiu, Michael Nguyen, Glen M Hocky, Aaron R Dinner, Suriyanarayanan Vaikuntanathan

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Adaptive nonequilibrium design of actin-based metamaterials: Fundamental and practical limits of control.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuqing QiuJames Franck Institute, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-0745-3155
Michael NguyenJames Franck Institute, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-3267-5462
Glen M HockyDepartment of Chemistry, New York University, New York, NY 10003.ORCID 0000-0002-5637-0698
Aaron R DinnerJames Franck Institute, University of Chicago, Chicago, IL 60637.ORCID 0000-0001-8328-6427
Suriyanarayanan VaikuntanathanJames Franck Institute, University of Chicago, Chicago, IL 60637; svaikunt@uchicago.edu.

Funding

Harnessing simulations to uncover molecular mechanisms of mechanosensingR35GM138312 · NIGMS · NEW YORK UNIVERSITY · PI Glen Hocky · 2020 to 2026
$3.0M
Rare-event simulation and analysis for elucidating mechanisms of development and diseaseR35GM136381 · NIGMS · UNIVERSITY OF CHICAGO · PI Aaron Dinner · 2020 to 2026
$2.2M
NIGMS NIH HHS R35 GM136381NIGMS NIH HHS R35 GM138312
6 · The paper itself

Abstract

Understanding the role of nonequilibrium driving in self-organization is crucial for developing a predictive description of biological systems, yet it is impeded by their complexity. The actin cytoskeleton serves as a paradigm for how equilibrium and nonequilibrium forces combine to give rise to self-organization. Motivated by recent experiments that show that actin filament growth rates can tune the morphology of a growing actin bundle cross-linked by two competing types of actin-binding proteins [S. L. Freedman

Indexed as

Actin CytoskeletonActinsBiopolymersMicrofilament ProteinsProtein TransportThermodynamicsActinsBiopolymersMicrofilament Proteinsactin bundling and growthfluctuation–response relationsmicroscopic nonequilibrium drivingstochastic thermodynamics

Identifiers

PMID34518221
PMCPMC8463841

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.