Evidence map›Paper›PMID 34518218›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Restoring fertility in yeast hybrids: Breeding and quantitative genetics of beneficial traits.

Samina Naseeb, Federico Visinoni, Yue Hu, Alex J Hinks Roberts, Agnieszka Maslowska, Thomas Walsh, Katherine A Smart, Edward J Louis, Daniela Delneri

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Polyploidy: A macromutational force pushing bioeconomic developments.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Isolation and characterization of haploid heterothallic beer yeasts.Applied microbiology and biotechnology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Evolution and molecular bases of reproductive isolation.Current opinion in genetics & development · 2022
    Review
  16. Article
  17. BeyondFrontiers in microbiology · 2022
    Article
  18. Article
  19. Article
  20. Lager Yeast Design Through Meiotic Segregation of aFrontiers in fungal biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Samina NaseebManchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, United Kingdom.ORCID 0000-0003-3599-5813
Federico VisinoniManchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, United Kingdom.ORCID 0000-0001-9840-7017
Yue HuDepartment of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, United Kingdom.
Alex J Hinks RobertsDepartment of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, United Kingdom.
Agnieszka MaslowskaDepartment of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, United Kingdom.
Thomas WalshDepartment of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, United Kingdom.
Katherine A SmartDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom.
Edward J LouisDepartment of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, United Kingdom; d.delneri@manchester.ac.uk ejl21@le.ac.uk.ORCID 0000-0003-1157-3608
Daniela DelneriManchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, United Kingdom; d.delneri@manchester.ac.uk ejl21@le.ac.uk.ORCID 0000-0001-8070-411X
University of Leicester · GBUniversity of Manchester · GBUniversity of Cambridge · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L017229/1Biotechnology and Biological Sciences Research Council BB/L021471/1Biotechnology and Biological Sciences Research Council BB/L022508/1
6 · The paper itself

Abstract

Hybrids between species can harbor a combination of beneficial traits from each parent and may exhibit hybrid vigor, more readily adapting to new harsher environments. Interspecies hybrids are also sterile and therefore an evolutionary dead end unless fertility is restored, usually via auto-polyploidisation events. In the

Indexed as

Acetic AcidCold TemperatureEthanolFermentationGenetic VariationGenome, FungalMitochondriaPhenotypeQuantitative Trait LociSaccharomycesSugarsAcetic AcidEthanolSugarsbreedinghybridsQTLyeast

Identifiers

PMID34518218
PMCPMC8463882
OpenAlexW3200843606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.