ArticleBMJ global health2021
Determinants of losses in the latent tuberculosis infection cascade of care in Brazil.
Article in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Challenges in implementing preventive treatment for latent tuberculosis infection: a narrative review from provider and demand-side perspectives.Frontiers in public health · 2025Pooled it
- Multimethod analysis of adherence to preventive treatment for tuberculosis: a pragmatic randomized clinical trial.BMC infectious diseases · 2026Trial
- Completion of tuberculosis preventive treatment with 300 mg vs. 100 mg isoniazid tablets: a pragmatic randomized clinical trial.BMC infectious diseases · 2025Trial
- Latent Tuberculosis and Associated Factors Among Adults Living With HIV in Kinshasa, Democratic Republic of the Congo: A Cross-Sectional Study.Public health challenges · 2026Article
- Body Mass Index and Incident Tuberculosis in Close Tuberculosis Contacts.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Observational
- Scaling Up Tuberculosis Preventive Treatment in the Brazilian Amazon (2016-2024): a Programmatic Report on Multi-sector Integration in Surveillance, Health Services and Academia.Revista da Sociedade Brasileira de Medicina Tropical · 2026Article
- Mycobacterium tuberculosis transmission among child and adolescent contacts of people with pulmonary tuberculosis in Brazil: a multi-center prospective cohort study.BMC infectious diseases · 2025Observational
- Community-Based Tuberculosis Preventive Treatment Among Child and Adolescent Household Contacts in Ethiopia.Tropical medicine and infectious disease · 2025Article
- Effect of Smoking on Longitudinal Interferon γ Release Assay Results Among Close Contacts of People with Pulmonary Tuberculosis.The Journal of infectious diseases · 2025Observational
- The yield of tuberculosis contact investigation in São Paulo, Brazil: a community-based cross-sectional study.Epidemiology and infection · 2025Article
- [The effect of the 3HP regimen on the completion of preventive tuberculosis treatment in people living with HIV: a retrospective cohort in Brazil].Cadernos de saude publica · 2025Article
- Clinical-Epidemiological Characteristics and Outcomes of Latent Tuberculosis Treatment at a Tertiary Center in Central-West Brazil from 2017 to 2019.Tropical medicine and infectious disease · 2022Article
- Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: A Brazilian multi-centre longitudinal study.Lancet regional health. Americas · 2022Article
- Possible sex difference in latent tuberculosis infection risk among close tuberculosis contacts.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Observational
- Latent Tuberculosis Cascade of Care Among Healthcare Workers: A Nationwide Cohort Analysis in Korea Between 2017 and 2018.Journal of Korean medical science · 2022Article
- The cascade of care for latent tuberculosis infection in congregate settings: A national cohort analysis, Korea, 2017-2018.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 4 countries.
Funding
Abstract
introductionFactors associated with losses in the latent tuberculosis infection (LTBI) cascade of care in contacts of patients with tuberculosis (TB) were investigated in a multicentre prospective cohort from highly endemic regions in Brazil.
methodsClose contacts of 1187 patients with culture-confirmed pulmonary TB were prospectively studied between 2015 and 2019, with follow-up of 6-24 months. Data on TB screening by clinical investigation, radiographic examination and interferon-gamma release assay (IGRA) were collected. Multivariable regressions were used to identify determinants of losses in the LTBI cascade.
resultsAmong 4145 TB contacts initially identified, 1901 were examined (54% loss). Among those examined, 933 were people living with HIV, ≤5 years old and/or had positive IGRA results, and therefore had a recommendation to start TB preventive treatment (TPT). Of those, 454 (23%) initiated treatment, and 247 (54% of those initiating; 26% of those in whom treatment was recommended) completed TPT. Multivariable regression analysis revealed that living with HIV, illiteracy and black/
conclusionThere were losses at all LTBI cascade stages, but particularly at the initial screening and examination steps. Close contacts of low socioeconomic status and living with HIV were at heightened risk of not completing the LTBI cascade of care in Brazil.
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