Evidence map›Paper›PMID 34517873›Full record

ArticleBMC pediatrics2021

Altered B cell compartment associated with Tfh cells in children with Henoch-Schonlein Purpura.

Ning Zhang, Ge Tian, Yuanyuan Sun, Jing Pan, Wei Xu, Zhe Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ning ZhangDepartment of Hematology, The First Affiliated Hospital of Jinzhou Medical University, No.2 Renmin Street, Liaoning, 121000, Jinzhou, People's Republic of China. ningzhang0505@sina.com.
Ge TianDepartment of Hematology, The First Affiliated Hospital of Jinzhou Medical University, No.2 Renmin Street, Liaoning, 121000, Jinzhou, People's Republic of China.
Yuanyuan SunDepartment of Hematology, The First Affiliated Hospital of Jinzhou Medical University, No.2 Renmin Street, Liaoning, 121000, Jinzhou, People's Republic of China.
Jing PanDepartment of Hematology, The First Affiliated Hospital of Jinzhou Medical University, No.2 Renmin Street, Liaoning, 121000, Jinzhou, People's Republic of China.
Wei XuDepartment of Hematology, The First Affiliated Hospital of Jinzhou Medical University, No.2 Renmin Street, Liaoning, 121000, Jinzhou, People's Republic of China.
Zhe LiDepartment of Hematology, The First Affiliated Hospital of Jinzhou Medical University, No.2 Renmin Street, Liaoning, 121000, Jinzhou, People's Republic of China. lz2205@126.com.
Jinzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimIgA-producing B cells have been found to be associated with children diagnosed with Henoch-Schonlein purpura (HSP). The aim of the present study was to determine whether children with HSP possess altered B-cell subsets.

methodsA total of 14 children diagnosed with HSP and age- and sex-matched healthy controls (HCs) were enrolled in our study. Peripheral blood mononuclear cells were isolated, and the percentage and absolute number of B-cell subsets and Follicular helper T (Tfh) cells were determined by flow cytometry. Finally, Spearman's correlation coefficient was used to analyse the correlation between the percentage of Tfh cells and B-cell subsets.

resultsWe found that compared to HCs, the frequency and absolute number of total B cells were significantly higher in children with HSP, but the percentages of plasma cells and naïve B cells were significantly lower. A significantly increased percentage and absolute number of memory nonswitched B cells were found in children with HSP compared with HCs. We observed that the expression of C-X-C chemokine receptor type 5 (CXCR5) on total CD4

conclusionsOur study showed a Tfh-cell-associated altered B cell compartment in children with HSP.

Indexed as

IgA VasculitisB-LymphocytesChildHumansLeukocytes, MononuclearT Follicular Helper CellsT-Lymphocytes, Helper-InducerB cellsCXCR5Henoch-Schonlein purpurasubsetsTfh

Identifiers

PMID34517873
PMCPMC8436472
OpenAlexW3116858064

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.