Evidence map›Paper›PMID 34517743›Full record

ArticlePharmaceutical biology2021

Pharmacokinetic study on the interaction between pachymic acid and bavachin and its potential mechanism.

Jie Zhang, Lu Liu, Hong Li, Bin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jie ZhangDepartment of Medicinal Medicine, The Second Hospital of Shandong University, Jinan, China.
Lu LiuDepartment of Endocrinology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China.
Hong LiDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Bin ZhangDepartment of Medicinal Medicine, The Second Hospital of Shandong University, Jinan, China.
Second Hospital of Shandong University · CNShanghai Tenth People's Hospital · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextPachymic acid and bavachin are commonly used drugs in the therapy of lung cancer.

objectiveThe co-administration of pachymic acid and bavachin was investigated to evaluate their potential drug-drug interaction. MATERIALS AND

methodsThe pharmacokinetics of bavachin (10 mg/kg) was studied in male Sprague-Dawley (SD) rats in the presence of pachymic acid (5 mg/kg) (

resultsPachymic acid influenced the pharmacokinetic profile of bavachin with the increased DISCUSSION AND

conclusionThe interaction between pachymic acid and bavachin results from the inhibition of CYP2C9 and

Indexed as

AnimalsArea Under CurveATP Binding Cassette Transporter, Subfamily B, Member 1Caco-2 CellsCytochrome P-450 Enzyme SystemDrug InteractionsFlavonoidsHalf-LifeHumansMaleMicrosomes, LiverRatsRats, Sprague-DawleyTriterpenesATP Binding Cassette Transporter, Subfamily B, Member 1bavachinCYP2C9 protein, ratCytochrome P-450 Enzyme SystemFlavonoidspachymic acidTriterpenesCYP2C9drug-drug interactionP-gp

Identifiers

PMID34517743
PMCPMC8439242
OpenAlexW3200387605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.