ArticleNature2021
Virus-induced senescence is a driver and therapeutic target in COVID-19.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 224 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
224citing papers in PubMed, 6 pooled it
21.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
224 citing papers in PubMed, 6 syntheses or guidelines pooled it, 339 citations in OpenAlex.
- Taurine supplementation as a therapeutic strategy for cellular senescence and chronic inflammation in long COVID: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- A dual-database bibliometric analysis of post-COVID-19 condition and cognitive dysfunction (2021-2025).Frontiers in neurology · 2026Pooled it
- Common and rare variant analyses reveal genetic factors underlying idiopathic pulmonary fibrosis and its shared aetiology with severe COVID-19.EBioMedicine · 2025Pooled it
- Cellular senescence in acute human infectious disease: a systematic review.Frontiers in aging · 2024Pooled it
- Tissue factor links inflammation, thrombosis, and senescence in COVID-19.Scientific reports · 2022Pooled it
- JAK inhibitors and COVID-19.Journal for immunotherapy of cancer · 2022Pooled it
- Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results.Nature medicine · 2025Trial
- Remodeling of innate antiviral immunity in aging.Cell insight · 2026Review
- Genomic, epigenomic and transcriptomic regulation of cellular senescence.Nature reviews. Genetics · 2026Review
- Is Cellular Senescence a Biological Feature of Long COVID? A Transcriptomic Analysis Across Comparative Postacute Sequelae Phenotypes.The Journal of infectious diseases · 2026Article
- Closing the gap in aging science: unlocking the potential of nanoparticles in senescence therapy.Biogerontology · 2026Review
- Oncoviruses at the Crossroads of Ageing and Cancer: Molecular Mechanisms and Key Signalling Pathways.Reviews in medical virology · 2026Review
- Pathological Mechanism-Inspired Biomimetic Nano-Senotherapy for Reversing Experimental Atherosclerosis in ApoEAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- [Misdirected intercellular communication in aging and chronic inflammation].Zeitschrift fur Gerontologie und Geriatrie · 2026Review
- SenFlag gene signature identifies senescent cells in mouse and human tissues through a conserved core transcriptional program.The EMBO journal · 2026Article
- Potential Adjunctive Effects of Quercetin-Curcumin Co-Supplementation in Adults with Mild-to-Moderate Long COVID: Results from a Pragmatic Exploratory Real-World Clinical Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Molecular mechanisms and recent advances in cellular senescence.Cell & bioscience · 2026Review
- Spatial cellular order underlies locally-confined mechanisms of immune resistance in oropharyngeal cancer.Nature communications · 2026Article
- Article
- Senescence-like cells recruit γδ T cells to drive prolonged hyposmia after SARS-CoV-2 infection in mice.EMBO reports · 2026Article
164 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
48 authors at 16 institutions in 6 countries.
Soyoung Lee *Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.ORCID http://orcid.org/0000-0002-4614-2931
Yong Yu *Medical Faculty, Johannes Kepler University, Linz, Austria.
Jakob TrimpertInstitute of Virology, Freie Universität Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-1616-0810
Fahad BenthaniMedical Faculty, Johannes Kepler University, Linz, Austria.ORCID http://orcid.org/0000-0002-3283-307X
Mario MairhoferMedical Faculty, Johannes Kepler University, Linz, Austria.
Paulina Richter-PechanskaMedical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.
Emanuel WylerMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID http://orcid.org/0000-0002-9884-1806
Dimitri BelenkiMedical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.ORCID http://orcid.org/0000-0002-9004-9849
Sabine KaltenbrunnerMedical Faculty, Johannes Kepler University, Linz, Austria.
Maria PammerMedical Faculty, Johannes Kepler University, Linz, Austria.
Lea KauscheMedical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.
Theresa C FirschingInstitute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-1378-4951
Kristina DietertInstitute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.
Michael SchotsaertDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-3156-3132
Carles Martínez-RomeroDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-8888-7715
Gagandeep SinghDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-3260-2631
Séverine KunzMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID http://orcid.org/0000-0002-0131-3506
Daniela NiemeyerInstitute of Virology, German Center for Infection Research (DZIF), Charité-Universitätsmedizin,, Berlin, Germany.ORCID http://orcid.org/0000-0002-1897-6365
Riad GhanemDepartment of Hematology and Oncology, Kepler University Hospital, Linz, Austria.
Helmut J F SalzerDepartment of Pulmonology, Kepler University Hospital, Linz, Austria.
Christian PaarLaboratory Medicine, Kepler University Hospital, Linz, Austria.
Michael MüllederCore Facility - High-Throughput Mass Spectrometry and Department of Biochemistry, Charité - Universitätsmedizin, Berlin, Germany.
Melissa UccelliniDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Edward G MichaelisInstitute of Pathology, Charité - Universitätsmedizin, Berlin, Germany.
Amjad KhanDepartment of Chemistry, University of Oxford, Oxford, UK.
Andrea LauMedical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.
Martin SchönleinMedical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.
Anna HabringerLaboratory Medicine, Kepler University Hospital, Linz, Austria.
Josef TomasitsLaboratory Medicine, Kepler University Hospital, Linz, Austria.
Julia M AdlerInstitute of Virology, Freie Universität Berlin, Berlin, Germany.
Susanne KimeswengerMedical Faculty, Johannes Kepler University, Linz, Austria.ORCID http://orcid.org/0000-0002-0443-8558
Achim D GruberInstitute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-4502-0393
Wolfram HoetzeneckerMedical Faculty, Johannes Kepler University, Linz, Austria.
Herta SteinkellnerDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
Bettina PurfürstMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Reinhard MotzInstitute of Pathology, Kepler University Hospital, Linz, Austria.
Francesco Di PierroScientific and Research Department, Velleja Research, Milan, Italy.
Bernd LamprechtMedical Faculty, Johannes Kepler University, Linz, Austria.ORCID http://orcid.org/0000-0003-3365-3449
Nikolaus OsterriederInstitute of Virology, Freie Universität Berlin, Berlin, Germany.
Markus LandthalerMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID http://orcid.org/0000-0002-1075-8734
Christian DrostenInstitute of Virology, German Center for Infection Research (DZIF), Charité-Universitätsmedizin,, Berlin, Germany.ORCID http://orcid.org/0000-0001-7923-0519
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6551-1827
Rupert LangerMedical Faculty, Johannes Kepler University, Linz, Austria.
Markus RalserCore Facility - High-Throughput Mass Spectrometry and Department of Biochemistry, Charité - Universitätsmedizin, Berlin, Germany.
Roland EilsCenter for Digital Health, Charité - Universitätsmedizin and Berlin Institute of Health (BIH), Berlin, Germany.ORCID http://orcid.org/0000-0002-0034-4036
Maurice ReimannMedical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.
Dorothy N Y FanMedical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.
Clemens A SchmittMedical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany. clemens.schmitt@charite.de.ORCID http://orcid.org/0000-0002-4731-2226
Johannes Kepler University of Linz · ATKepler Universitätsklinikum · ATMax Delbrück Center · DEFreie Universität Berlin · DECharité - Universitätsmedizin Berlin · DEIcahn School of Medicine at Mount Sinai · USBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEGerman Center for Infection Research · DEBOKU University · ATCity University of Hong Kong · HKGerman Marine Research Consortium · DERegeneron (United States) · USThe Francis Crick Institute · GBUniversität Hamburg · DEUniversity of Oxford · GBVelleja Research · IT
Funding
SARS-CoV adaptations through a Systems Biology Lens (SYBIL)U19AI135972 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Adolfo Garcia-Sastre · 2018 to 2026
$27.2MTechnology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Adolfo Garcia-Sastre, Anna Karolina Palucka · 2019 to 2026
$23.1MNIAID NIH HHS U19 AI135972NIAID NIH HHS U19 AI142733Wellcome Trust FC001134
Abstract
Derailed cytokine and immune cell networks account for the organ damage and the clinical severity of COVID-19 (refs.
Indexed as
COVID-19 Drug TreatmentMolecular Targeted TherapyAniline CompoundsAnimalsCell LineCellular SenescenceCOVID-19CricetinaeDasatinibDisease Models, AnimalFemaleHumansMaleMiceQuercetinSARS-CoV-2Aniline CompoundsDasatinibnavitoclaxQuercetinSulfonamides
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.