ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2021
Differential reinforcement learning responses to positive and negative information in unmedicated individuals with depression.
Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Neuropathophysiological changes associated with mirtazapine treatment response in major depressive disorder: insights into bottom-up dopaminergic pathways and prefrontal control networks.European archives of psychiatry and clinical neuroscience · 2026Article
- Arousal shapes motivation: an integrative framework for understanding motivational deficits.Translational psychiatry · 2026Review
- Antidepressant drugs have pharmacological- and time-dependent effects on reinforcement learning in healthy volunteers: An 8 weeks randomized double-blind placebo-controlled study.medRxiv : the preprint server for health sciences · 2026Article
- Cognitive-behavioral therapy to normalize social learning for patients with major depressive disorders: study protocol for a single-arm clinical trial.BMC psychology · 2025Article
- Alpha oscillatory dysregulation: mapping EEG oscillatory in suicidal depression.Frontiers in human neuroscience · 2025Article
- Personalizing esketamine treatment in TRD and TRBD: the role of mentalization, cognitive rigidity, psychache, and suicidality.Frontiers in psychiatry · 2025Article
- Reinforcement learning processes as forecasters of depression remission.Journal of affective disorders · 2025Article
- Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder.Molecular psychiatry · 2024Review
- Relationship between low mood and micro-expression processing: evidence of negative bias in interpreting fleeting facial expressions.Royal Society open science · 2024Article
- Negative valuation of ambiguous feedback may predict near-term risk for suicide attempt in Veterans at high risk for suicide.Frontiers in psychiatry · 2024Article
- Simulated synapse loss induces depression-like behaviors in deep reinforcement learning.Frontiers in computational neuroscience · 2024Article
- A feasibility study of goal-directed network-based real-time fMRI neurofeedback for anhedonic depression.Frontiers in psychiatry · 2023Article
- Plasticity of synapses and reward circuit function in the genesis and treatment of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Confirmation Bias in the Course of Instructed Reinforcement Learning in Schizophrenia-Spectrum Disorders.Brain sciences · 2022Article
- Trauma Disrupts Reinforcement Learning in Rats-A Novel Animal Model of Chronic Stress Exposure.Frontiers in behavioral neuroscience · 2022Article
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
Major depressive disorder (MDD) is characterized by behavioral and neural abnormalities in processing both rewarding and aversive stimuli, which may impact motivational and affective symptoms. Learning paradigms have been used to assess reinforcement encoding abnormalities in MDD and their association with dysfunctional incentive-based behavior, but how the valence and context of information modulate this learning is not well understood. To address these gaps, we examined responses to positive and negative reinforcement across multiple temporal phases of information processing. While undergoing functional magnetic resonance imaging (fMRI), 47 participants (23 unmedicated, predominantly medication-naïve participants with MDD and 24 demographically-matched HC participants) completed a probabilistic, feedback-based reinforcement learning task that allowed us to separate neural activation during motor response (choice) from reinforcement feedback and monetary outcome across two independent conditions: pursuing gains and avoiding losses. In the gain condition, MDD participants showed overall blunted learning responses (prediction error) in the dorsal striatum when receiving monetary outcome, and reduced responses in ventral striatum for positive, but not negative, prediction error. The MDD group showed enhanced sensitivity to negative information, and symptom severity was associated with better behavioral performance in the loss condition. These findings suggest that striatal responses during learning are abnormal in individuals with MDD but vary with the valence of information.
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