Evidence map›Paper›PMID 34517296›Full record

Trial reportJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2021

Post-Stroke Depression in Patients with Large Spontaneous Intracerebral Hemorrhage.

Radhika Avadhani, Richard E Thompson, Lourdes Carhuapoma, Gayane Yenokyan, Nichol McBee, Karen Lane, Noeleen Ostapkovich, Agnieszka Stadnik, Issam A Awad, Daniel F Hanley and 1 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Radhika AvadhaniDivision of Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Richard E ThompsonDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Lourdes CarhuapomaDivision of Neurocritical Care, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD, USA.
Gayane YenokyanDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Nichol McBeeDivision of Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Karen LaneDivision of Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Noeleen OstapkovichDivision of Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Agnieszka StadnikDepartment of Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Issam A AwadDepartment of Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Daniel F HanleyDivision of Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wendy C ZiaiDivision of Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Neurocritical Care, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: weziai@jhmi.edu.
Johns Hopkins University · USUniversity of Chicago · USJohns Hopkins Hospital · US

Funding

MISTIE III_ Lead Grant_ Cluster Application for the Clinical Coordinating CenterU01NS080824 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HANLEY, DANIEL F · 2013 to 2017
$23.2M
Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)U01NS106513 · NINDS · YALE UNIVERSITY · PI Hooman Kamel, Kevin Navin Sheth · 2019 to 2026
$20.6M
Microglia/macrophage polarization after intracerebral hemorrhageR01NS102583 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, RAYMOND CHARLES · 2018 to 2021
$1.8M
NINDS NIH HHS R01 NS102583NINDS NIH HHS U01 NS080824NINDS NIH HHS U01 NS106513
6 · The paper itself

Abstract

objectivesTo determine factors associated with post-stroke depression (PSD) and relationship between PSD and functional outcomes in spontaneous intracerebral hemorrhage (ICH) using prospective data from a large clinical trial. MATERIALS AND

methodsMISTIE III, a randomized, multicenter, placebo-controlled trial, was conducted to determine if minimally invasive surgery with thrombolysis improves outcome compared to standard medical care. Our primary outcome was post-stroke depression at 180 days. Secondary outcomes were change in blinded assessment of modified Rankin Scale (mRS) from 30 to 180 days, and from 180 to 365 days. Logistic regression models were used to assess the relationship between PSD and outcomes.

resultsAmong 379 survivors at day 180, 308 completed Center for Epidemiologic Studies Depression Scale, of which 111 (36%) were depressed. In the multivariable analysis, female sex (Adjusted Odds Ratio [AOR], 95% Confidence Interval [CI]: 1.93 [1.07-3.48]), Hispanic ethnicity (3.05 [1.19-7.85]), intraventricular hemorrhage (1.88 [1.02-3.45]), right-sided lesions (3.00 [1.43-6.29]), impaired mini mental state examination at day 30 (2.50 [1.13-5.54]), and not being at home at day 30 (3.17 [1.05-9.57]) were significantly associated with higher odds of PSD. Patients with PSD were significantly more likely to have unchanged or worsening mRS from day 30 to 180 (42.3% vs. 25.9%; p=0.004), but not from day 180 to 365.

conclusionsWe report high burden of PSD in patients with large volume ICH. Impaired cognition and not living at home may be more important than physical limitations in predicting PSD. Increased screening of high-risk post-stroke patients for depression, especially females and Hispanics may be warranted.

Indexed as

Cerebral HemorrhageDepressionStrokeSurvivorsFemaleHumansProspective StudiesRisk FactorsClinical outcomesCognitive impairmentIntracerebral hemorrhagePost-stroke depression

Identifiers

PMID34517296
PMCPMC8532502
OpenAlexW3199988858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.