Evidence map›Paper›PMID 34517214›Full record

ArticleCell calcium2021

Presenilin 1 is a direct regulator of the cardiac sarco/endoplasmic reticulum calcium pump.

Elisa Bovo, Roman Nikolaienko, Daniel Kahn, Ellen Cho, Seth L Robia, Aleksey V Zima

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elisa BovoDepartment of Cell and Molecular Physiology, Loyola University Chicago, IL, USA. Electronic address: ebovo@luc.edu.
Roman NikolaienkoDepartment of Cell and Molecular Physiology, Loyola University Chicago, IL, USA.
Daniel KahnDepartment of Cell and Molecular Physiology, Loyola University Chicago, IL, USA.
Ellen ChoDepartment of Cell and Molecular Physiology, Loyola University Chicago, IL, USA.
Seth L RobiaDepartment of Cell and Molecular Physiology, Loyola University Chicago, IL, USA.
Aleksey V ZimaDepartment of Cell and Molecular Physiology, Loyola University Chicago, IL, USA.
Loyola University Chicago · US

Funding

Structural Determinants of Calcium Pump RegulationR01HL092321 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia · 2008 to 2026
$8.9M
Structural Dynamics of Cardiac Muscle Calcium ATPase RegulationR01HL139065 · NHLBI · UNIVERSITY OF MINNESOTA · PI Robyn T Rebbeck, David D Thomas · 2020 to 2026
$5.2M
New mechanisms of SERCA regulation: Dimerization and MicropeptidesR01HL143816 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia, Gianluigi Veglia · 2019 to 2026
$3.6M
New mechanisms of SERCA2a regulation: role of luminal calciumR01HL151990 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI ZIMA, ALEKSEY V · 2021 to 2024
$1.7M
NHLBI NIH HHS R01 HL092321NHLBI NIH HHS R01 HL139065NHLBI NIH HHS R01 HL143816NHLBI NIH HHS R01 HL151990
6 · The paper itself

Abstract

The gamma secretase catalytic subunit presenilin 1 (PS1) is expressed in the endoplasmic reticulum (ER) of neurons, where it regulates Ca

Indexed as

CalciumEndoplasmic ReticulumHEK293 CellsHumansPresenilin-1Sarcoplasmic Reticulum Calcium-Transporting ATPasesCalciumPresenilin-1Sarcoplasmic Reticulum Calcium-Transporting ATPasesCa(2+) pumpCa(2+) transportEndoplasmic reticulumFRETHEK293 cellsPresenelin 1

Identifiers

PMID34517214
PMCPMC8541915
OpenAlexW3198767806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.