Evidence map›Paper›PMID 34517167›Full record

ArticleJournal of inorganic biochemistry2021

Comparison of phosphonate, hydroxypropyl and carboxylate pendants in Fe(III) macrocyclic complexes as MRI contrast agents.

Elizabeth A Kras, Samira M Abozeid, Waldine Eduardo, Joseph A Spernyak, Janet R Morrow

Open access · greenAbstract read
In one paragraph

Article in Journal of inorganic biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Fe(III)Inorganic chemistry · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Enzyme Control Over Ferric Iron Magnetostructural Properties.Angewandte Chemie (International ed. in English) · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Elizabeth A KrasDepartment of Chemistry, University at Buffalo, State University of New York, Amherst, NY 14260, United States of America.
Samira M AbozeidDepartment of Chemistry, University at Buffalo, State University of New York, Amherst, NY 14260, United States of America; Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, 35516 Mansoura, Egypt.
Waldine EduardoDepartment of Chemistry, University at Buffalo, State University of New York, Amherst, NY 14260, United States of America.
Joseph A SpernyakDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Institute, Buffalo, New York 14263, United States of America.
Janet R MorrowDepartment of Chemistry, University at Buffalo, State University of New York, Amherst, NY 14260, United States of America. Electronic address: jmorrow@buffalo.edu.
University at Buffalo, State University of New York · USRoswell Park Comprehensive Cancer Center · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CANDACE S JOHNSON · 1985 to 2026
$116.6M
High Field Electrospray/MALDI Fourier Transform Mass SpectrometerS10RR029517 · NCRR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WOOD, TROY D · 2010 to 2010
$1.7M
NCI NIH HHS P30 CA016056NCRR NIH HHS S10 RR029517
6 · The paper itself

Abstract

Fe(III) macrocyclic complexes containing a macrocycle and three pendant groups including phosphonate (NOTP =1,4,7-triazacyclononane-1,4,7-triyl-tris(methylenephosphonic acid), carboxylate (NOTA = 1,4,7 - triazacyclononane - N,N',N″ - triacetate) or hydroxypropyl (NOHP =(2S,2'S,2"S)-1,1',1″-(1,4,7-triazonane-1,4,7-triyl)tris(propan-2-ol)) were studied in order to compare the effect of these donor groups on solution chemistry and water proton relaxivity. All three complexes, Fe(NOTP), Fe(NOHP) and Fe(NOTA), display a large degree of kinetic inertness to dissociation in the presence of phosphate and carbonate, under acidic conditions of 100 mM HCl or 1 M HCl or to trans-metalation with Zn(II). The r

Indexed as

AnimalsContrast MediaCoordination ComplexesHeterocyclic Compounds, 1-RingIronLigandsMagnetic Resonance ImagingMiceMice, Inbred BALB CMolecular StructurePhosphorous AcidsWaterContrast MediaCoordination ComplexesHeterocyclic Compounds, 1-RingIronLigandsPhosphorous AcidsWaterCoordination chemistryIron complexesMice imagingMRIMRI contrast agentsSolution chemistry

Identifiers

PMID34517167
PMCPMC9124524
OpenAlexW3197850751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.