Evidence map›Paper›PMID 34517154›Full record

ArticleJournal of neuroimmunology2021

Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report.

Zahra Pourmoghaddas, Atefeh Sadeghizadeh, Seyedeh Zahra Tara, Alireza Zandifar, Hamid Rahimi, Rana Saleh, Mohammadreza Ghazavi, Omid Yaghini, Neda Hosseini, Niloofar Javadi and 2 more

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of neuroimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Zahra PourmoghaddasDepartment of Pediatric Infectious, Isfahan University of Medical Sciences, Isfahan, Iran.
Atefeh SadeghizadehDepartment of Pediatric Intensive Care, Isfahan University of Medical Sciences, Isfahan, Iran.
Seyedeh Zahra TaraDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alireza ZandifarDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hamid RahimiDepartment of Pediatric Infectious, Isfahan University of Medical Sciences, Isfahan, Iran.
Rana SalehDepartment of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammadreza GhazaviDepartment of Pediatric Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
Omid YaghiniDepartment of Pediatric Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
Neda HosseiniDepartment of Pediatric Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
Niloofar JavadiStudent Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad SaadatniaIsfahan Neurosciences Research Center, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: mosaadatnia@yahoo.com.
Arastoo VossoughDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Isfahan University of Medical Sciences · IRChildren's Hospital of Philadelphia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 infection can cause inflammatory reactions that could involve several organs. In the pediatric population, Multi-System Inflammatory Syndrome in Children (MIS-C) has been reported as one of the consequences of COVID-19. We report a unique pediatric COVID-19 patient with MIS-C, associated with paralysis of the extremities. MRI showed abnormal signal in the cervical spinal cord compatible with transverse myelitis. Methylprednisolone and IVIG were administered, without significant symptom improvement. As a next step, Infliximab was tried for her, and she responded remarkably well to this treatment. Infliximab may be considered as a treatment option in COVID-19 patients with transverse myelitis.

Indexed as

Antirheumatic AgentsChildCOVID-19COVID-19 Drug TreatmentFemaleHumansInfliximabMyelitis, TransverseSystemic Inflammatory Response SyndromeAntirheumatic AgentsInfliximabCOVID-19ImmunotherapyInfliximabMulti-System Inflammatory SyndromePediatricTransverse myelitis

Identifiers

PMID34517154
PMCPMC8397488
OpenAlexW3198494640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.