ArticleThe Journal of pediatrics2022
Depression in Female Adolescents with Heavy Menstrual Bleeding.
Article in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Adolescent Hormonal Contraceptive Use in the Context of Brain Development and Depression Risk: A Review and Considerations for Future Research.Biological psychiatry global open science · 2026Review
- Seventh Åland Island Meeting on von Willebrand Disease.Haemophilia : the official journal of the World Federation of Hemophilia · 2026Article
- Particular promotion of the intrauterine system to "vulnerable" adolescents: a qualitative exploration of hormonal contraceptive prescription practices.Reproductive health · 2026Article
- A novel transcutaneous auricular neurostimulation electrode configuration for treatment of heavy menstrual bleeding: an open-label trial.Bioelectronic medicine · 2026Article
- Von Willebrand disease: more than just a bleeding disorder.Research and practice in thrombosis and haemostasis · 2026Review
- Menstrual pattern and self-reported abnormal uterine bleeding in Brazilian adolescents: A multicenter cross-sectional study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Iron deficiency anemia is associated with depressive symptoms in adolescents with heavy menstrual bleeding.Research and practice in thrombosis and haemostasis · 2025Article
- The relationship between menstrual issues and depressive and anxiety symptoms in Chinese adolescent female inpatients: a cross-sectional questionnaire-based investigation.BMC psychology · 2025Article
- Menstrual Disorders Are Associated With Depressive Symptoms Among Women of Reproductive Age: Findings From the Korean Women's Health Survey for Sexual and Reproductive Health.Journal of Korean medical science · 2025Article
- Transcutaneous auricular neurostimulation to reduce heavy menstrual bleeding in women with and without von Willebrand disease.Frontiers in medicine · 2025Article
- Beyond the Cycle: Investigating the Relationship Between Menstrual Hygiene Factors, Family Economic Stability, and Depression Among Adolescent Girls in Uganda-A 24 Month Mixed-Effects Regression Analysis of the Suubi4Her Trial.International journal of women's health · 2025Article
- Menstrual Disorders in Adolescence: Diagnostic and Therapeutic Challenges.Journal of clinical medicine · 2024Review
- Depression and its association with menstrual disturbance among female university students: a cross-sectional study.BMJ public health · 2024Article
- Article
- Building the foundation for a community-generated national research blueprint for inherited bleeding disorders: research to advance the health of people with inherited bleeding disorders with the potential to menstruate.Expert review of hematology · 2023Article
- Building the foundation for a community-generated national research blueprint for inherited bleeding disorders: research priorities for ultra-rare inherited bleeding disorders.Expert review of hematology · 2023Article
- Symptom patterns and health service use of women in early adulthood: a latent class analysis from the Australian Longitudinal Study on Women's Health.BMC public health · 2023Article
- Health issues in women and girls affected by haemophilia with a focus on nomenclature, heavy menstrual bleeding, and musculoskeletal issues.Haemophilia : the official journal of the World Federation of Hemophilia · 2022Article
- "If I wasn't a girl": Experiences of adolescent girls with heavy menstrual bleeding and inherited bleeding disorders.Research and practice in thrombosis and haemostasis · 2022Article
- The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective.Nutrients · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo assess the degree to which heavy menstrual bleeding is associated with depression, independent of hormonal contraception. STUDY
designWe performed a retrospective cohort study of 1168 female adolescents 9-18 years old presenting to general pediatricians for heavy menstrual bleeding or well visits. Depression was the primary outcome and defined as a diagnosis in the health record. Univariable and multivariable regression models were fit to the data to identify factors associated with depression diagnosis.
resultsIn total, 581 adolescents with heavy menstrual bleeding and 587 without heavy menstrual bleeding were included. Depression diagnoses occurred with greater frequency in youth with heavy menstrual bleeding compared with those without heavy menstrual bleeding (50.9% vs 24.2% P < .001; risk ratio 1.67, 95% CI 1.39-2.01) but did not significantly differ between those taking vs not taking hormonal contraception (risk ratio 0.99; 95% CI 0.84-1.17). Most patients with depression and heavy menstrual bleeding developed depression following or concurrent with heavy menstrual bleeding (261/296, 88%). Of these, 199 of 261 (76%) were treated with hormonal contraception, but the majority (168/199; 84%) were diagnosed with depression before initiation.
conclusionsHeavy menstrual bleeding is associated with depression diagnosis in female adolescents. The use of hormonal contraception was not associated with depression diagnosis in multivariable analysis, covarying heavy menstrual bleeding, age, body mass index, anxiety, sexual activity, and substance use. As hormonal contraception is often used to treat heavy menstrual bleeding, heavy menstrual bleeding may be partially driving previous reports of increased depression risk in those taking hormonal contraception.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.