Evidence map›Paper›PMID 34516984›Full record

ArticleNeuropharmacology2021

Characterization of a differential reinforcement of low rates of responding task in non-deprived male and female rats: Role of Sigma-1 receptors.

Sabino Valentina, Angelo Blasio, Antonio Ferragud, Sema G Quadir, Malliga R Iyer, Kenner C Rice, Pietro Cottone

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sabino ValentinaLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, MA, USA. Electronic address: vsabino@bu.edu.
Angelo BlasioLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Antonio FerragudLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Sema G QuadirLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Malliga R IyerSection on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Kenner C RiceDrug Design and Synthesis, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Pietro CottoneLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, MA, USA. Electronic address: cottone@bu.edu.
Boston University · USNational Institute on Alcohol Abuse and Alcoholism · USNational Institute on Drug Abuse · US

Funding

Involvement of neuropeptide systems in excessive alcohol drinkingR01AA025038 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SABINO, VALENTINA · 2017 to 2021
$1.8M
Prefrontal cortex in excessive alcohol drinking: role of sigma receptorsR01AA024439 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SABINO, VALENTINA · 2016 to 2020
$1.8M
Neurobiology of compulsive eating.R01DA030425 · NIDA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COTTONE, PIETRO · 2011 to 2015
$1.6M
Role of sigma receptors in ethanol reinforcementR00AA016731 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SABINO, VALENTINA · 2009 to 2011
$732k
Alpha2 adrenergic receptors as a target for alcohol addictionR21AA029495 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COTTONE, PIETRO, SABINO, VALENTINA · 2022 to 2023
$433k
Determining the role of PACAP neuronal populations in alcohol drinking using PACAP-Cre miceR21AA026051 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COTTONE, PIETRO · 2018 to 2019
$433k
NIAAA NIH HHS R00 AA016731NIAAA NIH HHS R01 AA024439NIAAA NIH HHS R01 AA025038NIAAA NIH HHS R21 AA026051NIAAA NIH HHS R21 AA029495NIDA NIH HHS R01 DA030425
6 · The paper itself

Abstract

Impulsive action can be defined as the inability to withhold a response and represents one of the dimensions of the broad construct impulsivity. Here, we characterized a modified differential reinforcement of low rates of responding (DRL) task developed in our laboratory, in which impulsive action is measured in ad libitum fed/watered subjects. Specifically, we first determined the effects of both sex and estrous cycle on impulsive action by systematically comparing male and estrous-synchronized female subjects. In addition, we evaluated the convergent validity of this modified DRL task by testing the effects of the D

Indexed as

AnimalsAripiprazoleBehavior, AnimalChoice BehaviorDizocilpine MaleateDopamine D2 Receptor AntagonistsEstrous CycleFemaleImpulsive BehaviorMalePiperazinesRatsRats, WistarReceptors, N-Methyl-D-AspartateReceptors, sigmaSerotonin 5-HT2 Receptor Agonists1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazineAripiprazoleDizocilpine MaleateDopamine D2 Receptor AntagonistsPiperazinesReceptors, N-Methyl-D-AspartateReceptors, sigmaSerotonin 5-HT2 Receptor AgonistsSigma-1 ReceptorAripiprazoleEstrous cycleImpulsive actionImpulsivityMK-801Sigma-1 receptor

Identifiers

PMID34516984
PMCPMC9869339
OpenAlexW3199382221

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.