Evidence map›Paper›PMID 34516917›Full record

ArticleScience advances2021

Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination.

Tom G Caniels, Ilja Bontjer, Karlijn van der Straten, Meliawati Poniman, Judith A Burger, Brent Appelman, A H Ayesha Lavell, Melissa Oomen, Gert-Jan Godeke, Coralie Valle and 19 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it.

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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Tom G CanielsDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0001-9580-157X
Ilja BontjerDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0002-8406-7733
Karlijn van der StratenDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0001-6373-9302
Meliawati PonimanDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0001-8390-2058
Judith A BurgerDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Brent AppelmanCenter for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0002-4560-8410
A H Ayesha LavellDepartment of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0003-2838-5099
Melissa OomenDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Gert-Jan GodekeCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Coralie ValleCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.ORCID 0000-0003-3497-5378
Ramona MöglingCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Hugo D G van WilligenDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Elke WynbergDepartment of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Michiel SchinkelCenter for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0002-9357-9917
Lonneke A van VughtCenter for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Denise GuerraDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0003-4493-7885
Jonne L SnitselaarDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Devidas N ChaturbhujDepartment of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.ORCID 0000-0003-0276-0671
Isabel Cuella MartinDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0001-7543-3386
Amsterdam UMC COVID-19 S3/HCW study group
John P MooreDepartment of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.ORCID 0000-0002-9902-6096
Menno D de JongDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0002-8380-4738
Chantal ReuskenCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.ORCID 0000-0003-4605-9174
Jonne J SikkensDepartment of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0001-5481-5596
Marije K BomersDepartment of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0003-0399-6926
Godelieve J de BreeDepartment of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0002-5852-5833
Marit J van GilsDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0003-3422-8161
Dirk EgginkDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0002-4248-6008
Rogier W SandersDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.ORCID 0000-0002-2324-8573

Funding

Structural studies of native-like SOSIP trimersP01AI110657 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOORE, JOHN P · 2015 to 2024
$35.4M
Neutralization of Primate Immunodeficiency VirusesR01AI036082 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JOHN P MOORE · 1994 to 2026
$4.3M
NIAID NIH HHS P01 AI110657NIAID NIH HHS R01 AI036082
6 · The paper itself

Abstract

Emerging SARS-CoV-2 variants of concern (VOCs) pose a threat to human immunity induced by natural infection and vaccination. We assessed the recognition of three VOCs (B.1.1.7, B.1.351, and P.1) in cohorts of COVID-19 convalescent patients (

Identifiers

PMID34516917
PMCPMC8442901

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.