Evidence map›Paper›PMID 34516914›Full record

ArticleScience advances2021

Cristae-dependent quality control of the mitochondrial genome.

Christopher Jakubke, Rodaria Roussou, Andreas Maiser, Christina Schug, Felix Thoma, Raven Bunk, David Hörl, Heinrich Leonhardt, Peter Walter, Till Klecker and 1 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Review
  3. Diffusive spreading across dynamic mitochondrial network architectures.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Molecular machineries shaping the mitochondrial inner membrane.Nature reviews. Molecular cell biology · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Pediatric Chordoma: A Tale of Two Genomes.Molecular cancer research : MCR · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christopher JakubkeFaculty of Biology, Ludwig-Maximilian-Universität München, 82152 Planegg-Martinsried, Germany.
Rodaria RoussouFaculty of Biology, Ludwig-Maximilian-Universität München, 82152 Planegg-Martinsried, Germany.
Andreas MaiserFaculty of Biology, Ludwig-Maximilian-Universität München, 82152 Planegg-Martinsried, Germany.ORCID 0000-0002-2349-5822
Christina SchugZellbiologie, Universität Bayreuth, 95440 Bayreuth, Germany.
Felix ThomaFaculty of Biology, Ludwig-Maximilian-Universität München, 82152 Planegg-Martinsried, Germany.
Raven BunkFaculty of Biology, Ludwig-Maximilian-Universität München, 82152 Planegg-Martinsried, Germany.ORCID 0000-0001-9838-7626
David HörlFaculty of Biology, Ludwig-Maximilian-Universität München, 82152 Planegg-Martinsried, Germany.ORCID 0000-0003-1710-1708
Heinrich LeonhardtFaculty of Biology, Ludwig-Maximilian-Universität München, 82152 Planegg-Martinsried, Germany.ORCID 0000-0002-5086-6449
Peter WalterHoward Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-6849-708X
Till KleckerZellbiologie, Universität Bayreuth, 95440 Bayreuth, Germany.ORCID 0000-0003-0149-042X
Christof OsmanFaculty of Biology, Ludwig-Maximilian-Universität München, 82152 Planegg-Martinsried, Germany.ORCID 0000-0002-1892-0222

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial genomes (mtDNA) encode essential subunits of the mitochondrial respiratory chain. Mutations in mtDNA can cause a shortage in cellular energy supply, which can lead to numerous mitochondrial diseases. How cells secure mtDNA integrity over generations has remained unanswered. Here, we show that the single-celled yeast

Identifiers

PMID34516914
PMCPMC8442932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.