ArticleScience advances2021
Atypical genomic cortical patterning in autism with poor early language outcome.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed.
- Trial
- Dynamic Functional Synchronization Profiles in Autism Differ by Spatial Scale and Along Hierarchical Cortical Gradients.Biological psychiatry global open science · 2026Article
- Autism subtypes identified using cross-species functional connectivity analyses.Nature neuroscience · 2026Article
- Prenatal Ultrasound-Detected Structural Anomalies Associated with Autism Spectrum Disorder: A Narrative Review.Consortium psychiatricum · 2026Review
- Polygenic scores for autism are associated with reduced neurite density in adults and children from the general population.Molecular psychiatry · 2025Article
- Neuroanatomical basis of language ability in an autism subgroup with moderate language deficits.European child & adolescent psychiatry · 2025Article
- Biological subtyping of autism via cross-species fMRI.bioRxiv : the preprint server for biology · 2025Article
- A 3D approach to understanding heterogeneity in early developing autisms.Molecular autism · 2024Article
- Beyond the Spectrum: Subtype-Specific Molecular Insights into Autism Spectrum Disorder Via Multimodal Data Integration.medRxiv : the preprint server for health sciences · 2024Article
- Enhanced motor noise in an autism subtype with poor motor skills.Molecular autism · 2024Article
- Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Differences in regional brain structure in toddlers with autism are related to future language outcomes.Nature communications · 2024Article
- Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms.Molecular autism · 2024Article
- Polygenic scores for autism are associated with neurite density in adults and children from the general population.medRxiv : the preprint server for health sciences · 2024Article
- Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology.medRxiv : the preprint server for health sciences · 2023Article
- The molecular genetic landscape of human brain size variation.Cell reports · 2023Article
- Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism.Molecular psychiatry · 2023Article
- A predictive ensemble classifier for the gene expression diagnosis of ASD at ages 1 to 4 years.Molecular psychiatry · 2023Article
- Language, Social, and Face Regions Are Affected in Toddlers with Autism and Predictive of Language Outcome.Research square · 2023Article
- Absence of associations with prefrontal cortex and cerebellum may link to early language and social deficits in preschool children with ASD.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Cortical regionalization develops via genomic patterning along anterior-posterior (A-P) and dorsal-ventral (D-V) gradients. Here, we find that normative A-P and D-V genomic patterning of cortical surface area (SA) and thickness (CT), present in typically developing and autistic toddlers with good early language outcome, is absent in autistic toddlers with poor early language outcome. Autistic toddlers with poor early language outcome are instead specifically characterized by a secondary and independent genomic patterning effect on CT. Genes involved in these effects can be traced back to midgestational A-P and D-V gene expression gradients and different prenatal cell types (e.g., progenitor cells and excitatory neurons), are functionally important for vocal learning and human-specific evolution, and are prominent in prenatal coexpression networks enriched for high-penetrance autism risk genes. Autism with poor early language outcome may be explained by atypical genomic cortical patterning starting in prenatal development, which may detrimentally affect later regional functional specialization and circuit formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.