Evidence map›Paper›PMID 34516896›Full record

ArticleScience advances2021

Memory CD8

Marie Boutet, Zachary Benet, Erik Guillen, Caroline Koch, Saidi M'Homa Soudja, Fabien Delahaye, David Fooksman, Grégoire Lauvau

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Good neighbors make lasting memory.Nature immunology · 2026
    Article
  3. Article
  4. Article
  5. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  6. Single-Cell Transcriptomics Reveals CCL3Journal of inflammation research · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Transcriptomic Profiling Identifies CD8Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marie BoutetDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA.ORCID 0000-0002-6091-095X
Zachary BenetDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA.
Erik GuillenDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA.
Caroline KochDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA.
Saidi M'Homa SoudjaDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA.
Fabien DelahayeDepartment of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA.
David FooksmanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA.
Grégoire LauvauDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA.ORCID 0000-0002-3050-2664

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Enhancing Pathogen-specific Memory CD8+ T cell Responses in VivoR01AI103338 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LAUVAU, GREGOIRE STEPHANE · 2013 to 2022
$5.2M
Einstein Postbaccalaureate Research Education ProgramR25GM104547 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI AKABAS, MYLES H. · 2013 to 2023
$4.0M
CD138 Regulates Competition of Antibody Secreting Cells for SurvivalR01HL141491 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI David R Fooksman · 2018 to 2026
$3.8M
Enhancing Pathogen-Specific Memory CD8+ T cell Responses In VivoR56AI103338 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI LAUVAU, GREGOIRE STEPHANE · 2024 to 2024
$633k
Contribution of ASC Dynamics to Survival within the Bone MarrowF32HL149155 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BENET, ZACHARY LEO · 2019 to 2020
$124k
NCI NIH HHS P30 CA013330NHLBI NIH HHS F32 HL149155NHLBI NIH HHS R01 HL141491NIAID NIH HHS R01 AI103338NIAID NIH HHS R56 AI103338NIGMS NIH HHS R25 GM104547NIGMS NIH HHS T32 GM007288
6 · The paper itself

Abstract

While cognate antigen drives clonal expansion of memory CD8

Identifiers

PMID34516896
PMCPMC8442869

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.