Evidence map›Paper›PMID 34516892›Full record

ArticleScience advances2021

Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo.

Aref Shahini, Nika Rajabian, Debanik Choudhury, Shahryar Shahini, Kalyan Vydiam, Thy Nguyen, Joseph Kulczyk, Tyler Santarelli, Izuagie Ikhapoh, Yali Zhang and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Aref ShahiniBioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.ORCID 0000-0002-2744-2875
Nika RajabianBioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.ORCID 0000-0002-9963-4024
Debanik ChoudhuryBioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Shahryar ShahiniBioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.ORCID 0000-0003-3813-6424
Kalyan VydiamDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.ORCID 0000-0001-6298-3821
Thy NguyenDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Joseph KulczykBioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.ORCID 0000-0002-7118-1537
Tyler SantarelliDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.ORCID 0000-0003-0026-9344
Izuagie IkhapohBioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Yali ZhangDepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY 14260, USA.ORCID 0000-0002-8328-0591
Jianmin WangDepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY 14260, USA.ORCID 0000-0001-7527-0409
Song LiuDepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY 14260, USA.
Aimee StablewskiGene Targeting and Transgenic Shared Resource, Roswell Park Comprehensive Cancer Center.ORCID 0000-0001-9774-429X
Ramkumar ThiyagarajanDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Kenneth SeldeenDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.ORCID 0000-0003-1989-6698
Bruce R TroenDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.ORCID 0000-0002-3699-0021
Jennifer PeirickLaboratory Animal Facilities, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.ORCID 0000-0002-7613-2662
Pedro LeiBioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Stelios T AndreadisBioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.ORCID 0000-0001-9885-0457
University at Buffalo, State University of New York · USRoswell Park Comprehensive Cancer Center · USVA Western New York Healthcare System · US

Funding

Stem Cells for Vascular Tissue EngineeringR01HL086582 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ANDREADIS, STELIOS THEOHARIS · 2008 to 2017
$3.1M
Restoring the regenerative capacity of the aged muscleR01AG068250 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ANDREADIS, STELIOS THEOHARIS · 2020 to 2024
$2.0M
High throughput genetic and functional screens for restoring stem cell potentialR01AG052387 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ANDREADIS, STELIOS THEOHARIS · 2017 to 2019
$1.2M
Enhancing Geroscience Scholarship and Faculty Development to Minimize Frailty and Maximize HealthspanK07AG060266 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI TROEN, BRUCE R. · 2019 to 2023
$774k
The impacts of vitamin D status and HIIT on physical performance and frailty during agingR56AG065561 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI TROEN, BRUCE R. · 2020 to 2020
$760k
High intensity interval training and nicotinamide riboside treatment to enhance functional capacity and reduce frailty during agingI01BX004369 · VA · VA WESTERN NEW YORK HEALTHCARE SYSTEM · PI TROEN, BRUCE R. · 2019 to 2023
–
BLRD VA I01 BX004369NHLBI NIH HHS R01 HL086582NIA NIH HHS K07 AG060266NIA NIH HHS R01 AG052387NIA NIH HHS R01 AG068250NIA NIH HHS R56 AG065561
6 · The paper itself

Abstract

Senescence of myogenic progenitors impedes skeletal muscle regeneration. Here, we show that overexpression of the transcription factor NANOG in senescent myoblasts can overcome the effects of cellular senescence and confer a youthful phenotype to senescent cells. NANOG ameliorated primary hallmarks of cellular senescence including genomic instability, loss of proteostasis, and mitochondrial dysfunction. The rejuvenating effects of NANOG included restoration of DNA damage response via up-regulation of DNA repair proteins, recovery of heterochromatin marks via up-regulation of histones, and reactivation of autophagy and mitochondrial energetics via up-regulation of AMP-activated protein kinase (AMPK). Expression of NANOG in the skeletal muscle of a mouse model of premature aging restored the number of myogenic progenitors and induced formation of eMyHC

Identifiers

PMID34516892
PMCPMC8442867
OpenAlexW3198487034

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.