ArticleScience advances2021
Platelets amplify endotheliopathy in COVID-19.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 2 pooled it
10.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Toward standardization and a concerted vision for platelet proteomics research: communication from the SSC of the ISTH.Journal of thrombosis and haemostasis : JTH · 2025Guideline
- Endotheliopathy in Acute COVID-19 and Long COVID.International journal of molecular sciences · 2023Pooled it
- Effect of P2Y12 Inhibitors on Organ Support-Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Trial
- Subclinical neurovascular and immune correlates of post-COVID-19 syndrome detected by retinal imaging.Brain, behavior, & immunity - health · 2026Article
- Platelet-derived S100A9 contributes to endotheliopathy in alcohol-associated hepatitis.JCI insight · 2026Article
- Variation of the Neutrophil-to-Lymphocyte Ratio and Mean Platelet Volume in a Multicenter Study of Critically Ill Patients with COVID-19 Living at Different Altitudes.Medical sciences (Basel, Switzerland) · 2026Article
- A Component Analysis of Endotheliopathy of Trauma.Research square · 2026Article
- Circulating S100A8/A9 drives faster platelet COX-1 recovery via MRP4, impairing the duration of aspirin response.Blood advances · 2026Article
- Joint association of systemic inflammatory response index and thromboelastography maximum amplitude with the risk of early atherosclerosis in patients with rheumatoid arthritis.Clinical and experimental medicine · 2026Article
- The Platelet-Virus Axis in Human Disease.Viruses · 2026Review
- A platelet transcriptomic signature of thromboinflammation predicts cardiovascular risk.JCI insight · 2025Article
- Megakaryocyte phenotyping in response to SARS-CoV-2 variants.Platelets · 2025Article
- Platelets induce endothelial cell mitochondrial dysfunction in myocardial infarction.Science advances · 2025Article
- Characterizing the effect of bariatric surgery on circulating S100A9.International journal of obesity (2005) · 2025Article
- Review
- Evaluation of Function and Biochemical Parameters of Platelet Concentrates (PCs) Prepared From Blood Donors With a History of COVID-19 During the Platelet Storage.Journal of clinical laboratory analysis · 2025Article
- Tetraspanin CD37 regulates platelet hyperreactivity and thrombosis.Cardiovascular research · 2025Article
- Association of coagulation-related indicators with postoperative venous thromboembolism occurrence in patients with pituitary tumors.Scientific reports · 2025Article
- Endothelial growth media components alter SARS-CoV-2 spike-directed growth kinetics.Journal of virological methods · 2025Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 6 institutions in 1 country.
Tessa J BarrettDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-0751-1578
MacIntosh CornwellDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-3041-4410
Khrystyna MyndzarDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Christina C RollingDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Yuhe XiaDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-5723-7648
Kamelia DrenkovaDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Antoine BiebuyckDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Alexander T FieldsDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Michael TawilDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-6197-6010
Elliot Luttrell-WilliamsDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-4163-2445
Eugene YuriditskyDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Grace SmithCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6381-0391
Paolo CotziaDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Matthew D NealDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-8931-6236
Lucy Z KornblithDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1861-9691
Stefania PittalugaDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-7688-1439
Amy V RapkiewiczDepartment of Pathology, NYU Langone Long Island Hospital, New York University Langone Health, Mineola, NY, USA.ORCID 0000-0002-3438-022X
Hannah M BurgessDepartment of Microbiology, New York University Langone Health, New York, NY, USA.ORCID 0000-0003-3577-4746
Ian MohrDepartment of Microbiology, New York University Langone Health, New York, NY, USA.
Kenneth A StaplefordDepartment of Microbiology, New York University Langone Health, New York, NY, USA.
Deepak VooraDepartment of Medicine, Duke Center for Applied Genomics & Precision Medicine, Duke University School of Medicine, Durham, NC, USA.
Kelly RugglesInstitute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-0152-0863
Judith HochmanDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-5889-5981
Jeffrey S BergerDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-8216-4647
New York University · USNYU Langone Health · USUniversity of California, San Francisco · USDuke University · USNational Institutes of Health · USUniversity of Pittsburgh · US
Funding
ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7MProject-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 1985 to 2026
$83.1MControl of Translation in Herpesvirus Infected Cells - Resubmission - 1R01GM056927 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Ian J Mohr · 1999 to 2026
$7.6MMedical Scientist Research Service AwardT32GM136573 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SULMAN, ERIK · 2020 to 2024
$6.8MMechanisms of Platelet Activity in Vascular DiseaseR35HL144993 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BERGER, JEFFREY S · 2019 to 2025
$5.5MVirus Host Interactions that Regulate Translation in Cells Infected with HSV-1R01AI073898 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOHR, IAN J · 2008 to 2020
$5.0MMechanistic Elucidation and Targeted Therapy of Platelet Dysfunction After TraumaR35GM119526 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D · 2016 to 2025
$3.9MDevelopment Of Prognostic Platelet RNA Biomarkers To Tailor Antiplatelet TherapyR01HL118049 · NHLBI · DUKE UNIVERSITY · PI VOORA, DEEPAK · 2013 to 2017
$3.9MEPITRANSCRIPTOMIC REGULATION OF CYTOMEGALOVIRUS INFECTIONR01AI152543 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DEPLEDGE, DANIEL PEARCE, MOHR, IAN J · 2020 to 2025
$2.7MNCATS NIH HHS UL1 TR001445NCI NIH HHS P30 CA016087NHLBI NIH HHS OT2 HL156812NHLBI NIH HHS R01 HL118049NHLBI NIH HHS R35 HL144993NIAID NIH HHS R01 AI073898NIAID NIH HHS R01 AI152543NIGMS NIH HHS R01 GM056927NIGMS NIH HHS R35 GM119526NIGMS NIH HHS T32 GM136573
Abstract
Given the evidence for a hyperactive platelet phenotype in COVID-19, we investigated effector cell properties of COVID-19 platelets on endothelial cells (ECs). Integration of EC and platelet RNA sequencing revealed that platelet-released factors in COVID-19 promote an inflammatory hypercoagulable endotheliopathy. We identified
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.