Evidence map›Paper›PMID 34516877›Full record

ArticleScience advances2021

Ambipolar inverters based on cofacial vertical organic electrochemical transistor pairs for biosignal amplification.

Reem B Rashid, Weiyuan Du, Sophie Griggs, Iuliana P Maria, Iain McCulloch, Jonathan Rivnay

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
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  5. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. Dynamic Modulation of OECT-Based Inverters for In Situ Electrophysiological Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Controlling Ion Uptake in Carboxylated Mixed Conductors.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  15. An organic electrochemical neuron for a neuromorphic perception system.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Reem B RashidDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-9503-3881
Weiyuan DuPhysical Sciences and Engineering Division, KAUST Solar Center (KSC), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Sophie GriggsDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.ORCID 0000-0002-5916-6609
Iuliana P MariaDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.ORCID 0000-0002-9132-3555
Iain McCullochPhysical Sciences and Engineering Division, KAUST Solar Center (KSC), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.ORCID 0000-0002-6340-7217
Jonathan RivnayDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0602-6485

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

On-site signal amplification for bioelectronic sensing is a desirable approach to improving recorded signal quality and to reducing the burden on signal transmission and back-end electronics. While organic electrochemical transistors (OECTs) have been used as local transducers of bioelectronic signals, their current output presents challenges for implementation. OECT-based circuits offer new opportunities for high-performance signal processing. In this work, we introduce an active sensing node based on cofacial vertical OECTs forming an ambipolar complementary inverter. The inverter, which shows a voltage gain of 28, is composed of two OECTs on opposite side walls of a single active area, resulting in a footprint identical to a planar OECT. The inverter is used as an analog voltage preamplifier for recording electrocardiogram signals when biased at the input voltage corresponding to peak gain. We further demonstrate compatibility with nontraditional fabrication methods with potential benefits for rapid prototyping and large-area printed electronics.

Identifiers

PMID34516877
PMCPMC8442873

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.