Evidence map›Paper›PMID 34516872›Full record

ArticleScience advances2021

Interdependence of a mechanosensitive anion channel and glutamate receptors in distal wound signaling.

Jacob Moe-Lange, Nicoline M Gappel, Mackenzie Machado, Michael M Wudick, Cosima S A Sies, Stephan N Schott-Verdugo, Michele Bonus, Swastik Mishra, Thomas Hartwig, Margaret Bezrutczyk and 9 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
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  9. CaEMBO reports · 2025
    Article
  10. A unified framework for hydromechanical signaling can explain transmission of local and long-distance signals in plants.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
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  16. Review
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  19. Companion cell mediates wound-stimulated leaf-to-leaf electrical signaling.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 5 countries.

Jacob Moe-LangeDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4771-7618
Nicoline M GappelInstitute for Molecular Physiology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-4462-2384
Mackenzie MachadoDepartment of Plant Biology, Carnegie Science, Stanford, CA 94305, USA.
Michael M WudickInstitute for Molecular Physiology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-4332-369X
Cosima S A SiesInstitute for Molecular Physiology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0001-6169-047X
Stephan N Schott-VerdugoInstitute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0003-0735-1404
Michele BonusInstitute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0003-4411-7342
Swastik MishraComputational Cell Biology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.
Thomas HartwigInstitute for Molecular Physiology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-2707-2771
Margaret BezrutczykInstitute for Molecular Physiology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-8009-3635
Debarati BasuNSF Center for Engineering Mechanobiology, Department of Biology, Washington University in St. Louis, Box 1137, One Brookings Drive, St. Louis, MO 63130, USA.ORCID 0000-0003-0547-7636
Edward E FarmerDepartment of Plant Molecular Biology, University of Lausanne, CH-1015 Lausanne, Switzerland.
Holger GohlkeInstitute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0001-8613-1447
Andrey MalkovskiyDepartment of Plant Biology, Carnegie Science, Stanford, CA 94305, USA.ORCID 0000-0002-5648-8602
Elizabeth S HaswellNSF Center for Engineering Mechanobiology, Department of Biology, Washington University in St. Louis, Box 1137, One Brookings Drive, St. Louis, MO 63130, USA.ORCID 0000-0002-4246-065X
Martin J LercherComputational Cell Biology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0003-3940-1621
David W EhrhardtDepartment of Plant Biology, Carnegie Science, Stanford, CA 94305, USA.ORCID 0000-0001-6522-7722
Wolf B FrommerDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-6465-0115
Thomas J KleistInstitute for Molecular Physiology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0003-2568-7323
Heinrich Heine University Düsseldorf · DECarnegie Institution for Science · USWashington University in St. Louis · USJohn von Neumann Institute for Computing · DEUniversity of Lausanne · CHUniversity of Talca · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glutamate has dual roles in metabolism and signaling; thus, signaling functions must be isolatable and distinct from metabolic fluctuations, as seen in low-glutamate domains at synapses. In plants, wounding triggers electrical and calcium (Ca

Identifiers

PMID34516872
PMCPMC8442888
OpenAlexW3197507878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.