ArticleScience (New York, N.Y.)2021
Developmental chromatin programs determine oncogenic competence in melanoma.
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In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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107citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
107 citing papers in PubMed.
- Heterogeneity in cancer: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Changes in the transcriptome and synthetic lethal dependencies followingProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Origins and consequences of oncogenic 3D chromatin remodelling.Nature reviews. Cancer · 2026Review
- GNAQ Induces Melanomagenesis in Mitfa-Independent Melanocyte Progenitors in a Zebrafish Model of Uveal Melanoma.Cancer research · 2026Article
- Stem cells as an essential mediator of the exercise-tumorigenesis link.Nature reviews. Cancer · 2026Review
- Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability.PLoS computational biology · 2026Article
- Harnessing human tumor organoids for cancer modeling and precision therapy.Protein & cell · 2026Review
- Transcriptional Reprogramming by AP-1-Bound Cis-Regulatory Elements Is Associated with Melanoma Development.International journal of molecular sciences · 2026Article
- Ginsenoside Rg3 inhibits melanoma progression by inducing ferroptosis via the p53/SLC7A11/GPX4 pathway.Journal of advanced research · 2026Article
- Developmental timing distinguishes pediatric and adult cancers through retention and rewiring mechanisms.Nature communications · 2026Review
- Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation.Developmental cell · 2026Article
- Neural crest gene regulatory networks as drivers of development, diversification and disease.Nature reviews. Molecular cell biology · 2026Review
- A Targetable Developmental Program Coregulates Angiogenesis and Immune Evasion in Melanoma.Cancer discovery · 2026Article
- Beyond Darwin: reactive heredity, burst-drift dynamics and eco‑evolutionary control of cancer.Molecular cancer · 2026Review
- Beyond the chaos: How architecture structures tumour biology.The FEBS journal · 2026Review
- Tissue-specific inflammation induces cell state plasticity with oncogenic addiction in mucosal melanoma.Science advances · 2026Article
- Tumour promotion through the lens of evolution.Nature · 2026Review
- Review
- Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability.bioRxiv : the preprint server for biology · 2026Article
- Bromodomain-Driven Regulation of Stem Cells: A Potential Target for Cancer Therapeutic Intervention.Stem cell reviews and reports · 2026Review
47 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors.
Arianna Baggiolini *Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-2476-561X
Scott J Callahan *Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Emily MontalDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0001-7855-3631
Joshua M WeissDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0001-7340-4004
Tuan TrieuInstitute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10021, USA.
Mohita M TagoreDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-2586-1427
Sam E TischfieldDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-5717-3856
Ryan M WalshCenter for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Shruthy SureshDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-2985-8284
Yujie FanCenter for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0001-8642-0695
Nathaniel R CampbellDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-0355-0708
Sarah C PerleeDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0003-3295-6755
Nathalie SauratCenter for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-6439-5166
Miranda V HunterDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-6971-1738
Theresa Simon-VermotDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-2814-2903
Ting-Hsiang HuangDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0001-8739-0571
Yilun MaDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-2297-9980
Travis HollmannDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0003-1599-0433
Satish K TickooDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-9775-0478
Barry S TaylorDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-3355-9471
Ekta KhuranaInstitute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10021, USA.ORCID 0000-0002-4351-7566
Richard P KocheCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-6820-5083
Lorenz Studer *Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0003-0741-7987
Richard M White *Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0001-9099-9169
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MWeill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MTRAINING PROGRAM IN MOLECULAR AND CELLULAR BIOLOGYT32GM008539 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BROWN, ANTHONY M.C. · 1995 to 2020
$5.0MDissecting the complexity of metastasis with mathematical models and quantitative experiments with in zebrafishR01CA229215 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI WHITE, RICHARD MARK, XAVIER, JOAO · 2018 to 2022
$3.1MEvolutionary dynamics of melanoma metastasisDP2CA186572 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI WHITE, RICHARD MARK · 2013 to 2013
$2.7MLipid programs in melanocyte transformationR01CA238317 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI OVERHOLTZER, MICHAEL H., WHITE, RICHARD MARK · 2020 to 2025
$2.0MThe role of melanocyte precursors in zebrafish pigmentation disordersK08AR055368 · NIAMS · SLOAN-KETTERING INST CAN RESEARCH · PI WHITE, RICHARD MARK · 2009 to 2013
$635kInvestigating cancer metabolism and its potential for therapeutic interventionK00CA223016 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI MONTAL, EMILY DINA · 2019 to 2022
$391kProbing schizophrenia associated neurodevelopmental defects in integrated neocortical organoidsF32MH116590 · NIMH · SLOAN-KETTERING INST CAN RESEARCH · PI WALSH, RYAN · 2019 to 2021
$208kDissecting the Ecology of Metastasis in a Zebrafish Model: Trade-Offs of Size and Diversity in Circulating Tumor Cell ClustersF30CA220954 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CAMPBELL, NATHANIEL R · 2018 to 2021
$194kInvestigating the Role of Adipocyte Lipolysis in Melanoma ProgressionF30CA236442 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI WEISS, JOSHUA M. · 2019 to 2022
$186kMalignant melanoma studies using iPS derived melanocytes and ZebrafishF31CA196305 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CALLAHAN, SCOTT JAMES · 2015 to 2018
$155kNCI NIH HHS DP2 CA186572NCI NIH HHS F30 CA220954NCI NIH HHS F30 CA236442NCI NIH HHS F31 CA196305NCI NIH HHS K00 CA223016NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA229215NCI NIH HHS R01 CA238317NIAMS NIH HHS K08 AR055368NIGMS NIH HHS T32 GM007739NIGMS NIH HHS T32 GM008539NIMH NIH HHS F32 MH116590
Abstract
Oncogenes only transform cells under certain cellular contexts, a phenomenon called oncogenic competence. Using a combination of a human pluripotent stem cell–derived cancer model along with zebrafish transgenesis, we demonstrate that the transforming ability of BRAF
Indexed as
AnimalsAnimals, Genetically ModifiedATPases Associated with Diverse Cellular ActivitiesCarcinogenesisChromatinDNA-Binding ProteinsHumansMelanocytesMelanomaMiceNeoplasms, ExperimentalNeoplastic Stem CellsNeural CrestPluripotent Stem CellsProto-Oncogene Proteins B-rafSOXE Transcription FactorsATAD2 protein, humanATPases Associated with Diverse Cellular ActivitiesBRAF protein, humanChromatinDNA-Binding ProteinsProto-Oncogene Proteins B-rafSOX10 protein, humanSOXE Transcription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.