ArticleScience translational medicine2021
JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
12.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- [Meta-analysis of the effects of PDL combined with fractional carbon dioxide laser in the treatment of hypertrophic scars in children].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Pooled it
- Fibroblasts in Scar Formation: Biology and Clinical Translation.Oxidative medicine and cellular longevity · 2022Pooled it
- Spatial anchoring of lipid metabolism shapes immune fate in the tumor microenvironment.Lipids in health and disease · 2026Review
- The Adjunctive Role of Botulinum Toxin A in Wound Healing and Scar Management.Aesthetic plastic surgery · 2026Review
- γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response.Nature communications · 2026Article
- Spatiotemporally controlled restoration of GAS6 signaling via mRNA therapy promotes scarless healing in preclinical models.Nature communications · 2026Article
- Mesenchymal Stem Cells-Derived Exosomes: Next-Generation Nanomedicines Toward Scarless Wound Healing.International journal of nanomedicine · 2026Review
- Platelet-Rich Plasma (PRP) bidirectionally modulates scar formation via the Piezo1-YAP/TAZ axis: a novel mechanotransduction hypothesis.Frontiers in cell and developmental biology · 2026Article
- Exploration of novel therapeutic targets for keloids based on clinical and molecular data: the role of the IL-4/IL-13 signaling pathway.European journal of medical research · 2025Article
- Hyperglycemia Induced in Sprague-Dawley Rats Modulates the Expression of CD36 and CD69 During Wound Healing.International journal of molecular sciences · 2025Article
- Sustained-Release Sitagliptin Microneedles for Scar Prevention via Fibroblast-to-Adipocyte Conversion.Small science · 2025Article
- Cellular and Molecular Mechanisms of Wound Repair: From Biology to Therapeutic Innovation.Cells · 2025Review
- Multi-omic analysis reveals retinoic acid molecular drivers for dermal fibrosis and regenerative repair in the skin.Cell stem cell · 2025Article
- Osteopontin attenuates the foreign-body response to silicone implants.Nature biomedical engineering · 2025Article
- Personalized human umbilical cord mesenchymal stem cell-derived exosome pre-treatment based on the simulation of scar microenvironment characteristics: a promising approach for early scar treatment.Molecular biology reports · 2025Article
- Growth arrest specific-6 and angiotoxin receptor-like signaling drive oral regenerative wound repair.Science translational medicine · 2025Article
- Article
- CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription.Cell death & disease · 2025Article
- A dynamically phase-adaptive regulating hydrogel promotes ultrafast anti-fibrotic wound healing.Nature communications · 2025Article
- Suture-Mediated Delivery System Reduces the Incidence of Uterine Scarring Through the TGF-β Pathway.Journal of functional biomaterials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 5 institutions in 1 country.
Michelle F GriffinHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-2027-547X
Mimi R BorrelliHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-7359-5074
Julia T GarciaCenter for Personal Dynamics Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michael JanuszykHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Megan KingHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Tristan LerbsDepartment of Pathology, Stanford School of Medicine, Stanford, CA 94305, USA.
Lu CuiDepartment of Pathology, Stanford School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-3531-8102
Alessandra L MooreHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-7815-178X
Abra H ShenHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-6110-0510
Shamik MascharakHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-0258-8832
Nestor M Diaz DeleonHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sandeep AdemHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Walter L TaylorHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-2524-2968
Heather E desJardins-ParkHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-0250-925X
Marc GastouDepartment of Pathology, Stanford School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-3030-4809
Ronak A PatelHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bryan A DuotoHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jan SokolHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-0764-8737
Yuning WeiCenter for Personal Dynamics Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA.
Deshka FosterHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-8372-4722
Kellen ChenHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-7023-7850
Derrick C WanHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-4666-1683
Geoffrey C GurtnerHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-6118-7161
Hermann P LorenzHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-9287-145X
Howard Y ChangCenter for Personal Dynamics Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-9459-4393
Gerlinde WernigDepartment of Pathology, Stanford School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-5169-8731
Michael T LongakerHagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-1430-8914
Stanford University · USStanford Medicine · USCalifornia Institute for Regenerative Medicine · USCal Poly Humboldt · USHoward Hughes Medical Institute · US
Funding
Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI GREENLEAF, WILLIAM JAMES · 2014 to 2018
$15.2MCenter for Personal Dynamic RegulomesRM1HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2019 to 2023
$13.8MIrradiated head and neck cancer soft tissue reconstruction by fat transfer.R01DE027346 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, WAN, DERRICK · 2018 to 2022
$1.9MMechanoresponsive Engrailed-1-negative fibroblasts activate Engrailed-1 to promote fibrosis in wound healingR01GM136659 · NIGMS · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2020 to 2023
$1.3MFibroblast lineage mechanisms of scarless skin healingR01GM116892 · NIGMS · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, LORENZ, HERMANN PETER · 2017 to 2020
$1.2MImmune Checkpoint Inhibitors as Antifibrotic Therapy for Idiopathic Pulmonary FibrosisK08HL143143 · NHLBI · STANFORD UNIVERSITY · PI WERNIG, GERLINDE · 2018 to 2020
$502kHoward Hughes Medical InstituteNHGRI NIH HHS P50 HG007735NHGRI NIH HHS RM1 HG007735NHLBI NIH HHS K08 HL143143NIDCR NIH HHS R01 DE027346NIGMS NIH HHS R01 GM116892NIGMS NIH HHS R01 GM136659
Abstract
Pathologic skin scarring presents a vast economic and medical burden. Unfortunately, the molecular mechanisms underlying scar formation remain to be elucidated. We used a hypertrophic scarring (HTS) mouse model in which
Indexed as
CD36 AntigensCicatrix, HypertrophicProto-Oncogene Proteins c-junSkin DiseasesAnimalsHumansMiceSkinCD36 AntigensJUN protein, humanProto-Oncogene Proteins c-jun
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.