ArticleScience (New York, N.Y.)2021
Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction.
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Proposing a "Brain Health Checkup (BHC)" as a Global Potential "Standard of Care" to Overcome Reward Dysregulation in Primary Care Medicine: Coupling Genetic Risk Testing and Induction of "Dopamine Homeostasis".International journal of environmental research and public health · 2022Pooled it
- Mitochondrial calcium influx-driven bioenergetics selectively enable drug addiction.Nature neuroscience · 2026Article
- Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior.Nature neuroscience · 2026Article
- Superior colliculus modulates the compulsion in a model of addiction with foot-shock.Translational psychiatry · 2026Article
- Structural connectome architecture and biological vulnerability shape cortical atrophy in cocaine use disorder.BMC medicine · 2026Article
- Social reward outcompetes drug seeking dopaminergic ensembles to prevent relapse.Nature communications · 2026Article
- Cocaine Use Disorder: Neuropathology and Exploratory Treatments.Molecular neurobiology · 2026Review
- Dopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward.Nature communications · 2026Article
- D2 autoreceptors gate vulnerability to cocaine use disorder.bioRxiv : the preprint server for biology · 2026Article
- The Serotonin 1B Receptor Modulates Striatal Activity Differentially Based on Behavioral Context.eNeuro · 2026Article
- Dopamine signatures of excessive and compulsive cocaine and fentanyl use.bioRxiv : the preprint server for biology · 2026Article
- 5-HTMolecular psychiatry · 2025Article
- The serotonin 1B receptor modulates striatal activity differentially based on behavioral context.bioRxiv : the preprint server for biology · 2025Article
- Pharmacological Evaluation of Tropane Analogues at the Serotonin Transporter.ACS chemical neuroscience · 2025Article
- Article
- Remission from addiction: erasing the wrong circuits or making new ones?Nature reviews. Neuroscience · 2025Review
- Similarities and Differences in Neurobiology.Advances in experimental medicine and biology · 2025Review
- The Dopamine System in Mediating Alcohol Effects in Humans.Current topics in behavioral neurosciences · 2025Review
- Probiotics alleviate chronic ethanol exposure-induced anxiety-like behavior and hippocampal neuroinflammation in male mice through gut microbiota-derived extracellular vesicles.Journal of nanobiotechnology · 2024Article
- Article
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10 authors.
Funding
Abstract
Compulsive drug use despite adverse consequences defines addiction. While mesolimbic dopamine signaling is sufficient to drive compulsion, psychostimulants such as cocaine also boost extracellular serotonin (5-HT) by inhibiting reuptake. We used SERT Met172 knockin (SertKI) mice carrying a transporter that no longer binds cocaine to abolish 5-HT transients during drug self-administration. SertKI mice showed an enhanced transition to compulsion. Conversely, pharmacologically elevating 5-HT reversed the inherently high rate of compulsion transition with optogenetic dopamine self-stimulation. The bidirectional effect on behavior is explained by presynaptic depression of orbitofrontal cortex–to–dorsal striatum synapses induced by 5-HT via 5-HT
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.