Evidence map›Paper›PMID 34516789›Full record

ArticleScience (New York, N.Y.)2021

Regulation of biomolecular condensates by interfacial protein clusters.

Andrew W Folkmann, Andrea Putnam, Chiu Fan Lee, Geraldine Seydoux

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  9. bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Oligomerization of PER2 as a dynamic mode of regulation of the mammalian circadian clock.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. Theoretical limits for sensing through phase separation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Review

85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Andrew W Folkmann *Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0003-2726-6987
Andrea Putnam *Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-7985-142X
Chiu Fan LeeDepartment of Bioengineering, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0003-4363-9050
Geraldine SeydouxDepartment of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-8257-0493

Funding

Regulation of Germ Cell Fate During EmbryogenesisR37HD037047 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SEYDOUX, GERALDINE CATHERINE JOELLE · 2016 to 2025
$3.8M
LSM880 Laser-scanning Microscope with Airyscan ModuleS10OD023548 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2018 to 2018
$439k
The role of gel-like scaffolds in RNA granule assemblyF32GM134630 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI PUTNAM, ANDREA ARLTON · 2019 to 2019
$64k
Howard Hughes Medical InstituteNICHD NIH HHS R37 HD037047NIGMS NIH HHS F32 GM134630NIH HHS S10 OD023548
6 · The paper itself

Abstract

Biomolecular condensates are cellular compartments that can form by phase separation in the absence of limiting membranes. Studying the P granules of

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsIntrinsically Disordered ProteinsOocytesProtein-Tyrosine KinasesRNA-Binding ProteinsZygoteCaenorhabditis elegans ProteinsIntrinsically Disordered ProteinsMBK-2 protein, C elegansMEG-3 protein, C elegansPGL-3 protein, C elegansProtein-Tyrosine KinasesRNA-Binding Proteins

Identifiers

PMID34516789
PMCPMC8627561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.