ArticleScience advances2021
Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- From optical control to translational readiness: an evidence-tiered framework for optogenetics in neuromuscular and neurological disorders.Materials today. Bio · 2026Review
- Integrative Transcriptomic and Network-Based Analysis of Neuromuscular Diseases.International journal of molecular sciences · 2025Article
- Engineered human myogenic cells in hydrogels generate innervated vascularized myofibers within dystrophic mouse muscle on long-term engraftment.Cell reports. Medicine · 2025Article
- Unlocking the Complexity of Neuromuscular Diseases: Insights from Human Pluripotent Stem Cell-Derived Neuromuscular Junctions.International journal of molecular sciences · 2023Review
- A scalable human iPSC-based neuromuscular disease model on suspended biobased elastomer nanofiber scaffolds.Biofabrication · 2023Article
- Duchenne muscular dystrophy: pathogenesis and promising therapies.Journal of neurology · 2023Review
- 3D human induced pluripotent stem cell-derived bioengineered skeletal muscles for tissue, disease and therapy modeling.Nature protocols · 2023Review
- 3D Compartmentalised Human Pluripotent Stem Cell-derived Neuromuscular Co-cultures.Bio-protocol · 2023Article
- Enrichment of human embryonic stem cell-derived V3 interneurons using an Nkx2-2 gene-specific reporter.Scientific reports · 2023Article
- Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction.Journal of visualized experiments : JoVE · 2022Article
- Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy.Journal of cachexia, sarcopenia and muscle · 2022Article
- Neuromuscular Development and Disease: Learning FromFrontiers in cell and developmental biology · 2021Review
- Uncovering the Embryonic Origins of Duchenne Muscular Dystrophy.WIREs mechanisms of diseaseArticle
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 6 institutions in 3 countries.
Amaia Paredes-RedondoCentre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.ORCID 0000-0002-9504-8423
Peter HarleyCentre for Stem Cells and Regenerative Medicine, MRC Centre for Neurodevelopmental Disorders, and Centre for Developmental Neurobiology, King's College London, London, UK.ORCID 0000-0001-6689-0227
Eleni ManiatiCentre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
David RyanWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0001-8906-2379
Sandra LouzadaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0003-2245-8453
Jinhong MengUCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.ORCID 0000-0002-8405-8140
Anna KowalaCentre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.ORCID 0000-0003-2887-0393
Beiyuan FuWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Fengtang YangWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0002-3573-2354
Pentao LiuSchool of Biomedical Sciences, Stem Cell and Regenerative Medicine Consortium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.ORCID 0000-0001-5774-9678
Silvia MarinoCentre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.
Olivier PourquiéDepartment of Genetics and Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA, USA.ORCID 0000-0001-5189-1227
Francesco MuntoniUCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.ORCID 0000-0002-9102-5232
Jun WangCentre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.ORCID 0000-0003-2509-9599
Ivo LieberamCentre for Stem Cells and Regenerative Medicine, MRC Centre for Neurodevelopmental Disorders, and Centre for Developmental Neurobiology, King's College London, London, UK.ORCID 0000-0003-3539-3054
Yung-Yao LinCentre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.ORCID 0000-0002-0435-7694
Queen Mary University of London · GBWellcome Sanger Institute · GBGreat Ormond Street Hospital · GBKing's College London · GBBrigham and Women's Hospital · USChinese University of Hong Kong · HK
Funding
Medical Research Council G0802546Medical Research Council MR/N025865/1Medical Research Council MR/W006251/1Wellcome Trust
Abstract
Duchenne muscular dystrophy (DMD) is caused by
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.