Evidence map›Paper›PMID 34516610›Full record

ArticleThe Journal of cell biology2021

A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?

Yeojin Lee, Lei Ding

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yeojin LeeColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0002-5548-5346
Lei DingColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0003-4869-8877
Columbia University · US

Funding

Understanding the role of stellate cells in the liver hematopoietic stem cell nicheR01HL153487 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DING, LEI · 2020 to 2024
$2.8M
Understanding and targeting bone marrow microenvironment in myelofibrosisR01HL155868 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DING, LEI · 2021 to 2024
$2.3M
NHLBI NIH HHS R01 HL153487NHLBI NIH HHS R01HL153487NHLBI NIH HHS R01 HL155868
6 · The paper itself

Abstract

Multipotent hematopoietic stem cells are maintained by the bone marrow niche, but how niche-derived membrane-bound stem cell factor (mSCF) regulates HSCs remains unclear. In this issue, Hao et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010118) describe that mSCF, synergistically with VCAM-1, induces large, polarized protrusions that serve as anchors for HSCs to their niche.

Indexed as

Hematopoietic Stem CellsStem Cell NicheBone Marrow CellsSynapses

Identifiers

PMID34516610
PMCPMC8441858
OpenAlexW3199588379

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.