Evidence map›Paper›PMID 34516254›Full record

ArticleAntimicrobial agents and chemotherapy2021

Olumide Martins, Jin Lee, Amit Kaushik, Nicole C Ammerman, Kelly E Dooley, Eric L Nuermberger

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Olumide MartinsCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.
Jin LeeCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.
Amit KaushikCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5622-1721
Nicole C AmmermanCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-9359-9144
Kelly E DooleyCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-9013-5256
Eric L NuermbergerCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-1440-9889
Johns Hopkins University · US

Funding

Mentoring Investigators in HIV and Tuberculosis Therapeutics ResearchK24AI150349 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DOOLEY, KELLY E. · 2020 to 2025
$789k
Exploiting a robust drug discovery portfolio to develop effective regimens to treat Mycobacterium abscessus lung infectionR21AI137814 · NIAID · JOHNS HOPKINS UNIVERSITY · PI NUERMBERGER, ERIC L · 2018 to 2019
$450k
Cystic Fibrosis Foundation (CFF)HHS | National Institutes of Health (NIH) K24-AI150349HHS | National Institutes of Health (NIH) R21-AI137814NIAID NIH HHS K24 AI150349NIAID NIH HHS R21 AI137814Roche Holding | Genentech (Genentech Inc) Research Fellowship Award
6 · The paper itself

Abstract

Mycobacterium abscessus lung disease is difficult to treat due to intrinsic drug resistance and the persistence of drug-tolerant bacteria. Currently, the standard of care is a multidrug regimen with at least 3 active drugs, preferably including a β-lactam (imipenem or cefoxitin). These regimens are lengthy and toxic and have limited efficacy. The search for more efficacious regimens led us to evaluate bedaquiline, a diarylquinoline licensed for treatment of multidrug-resistant tuberculosis. We performed

Indexed as

Mycobacterium abscessusMycobacterium Infections, NontuberculousAnti-Bacterial AgentsDiarylquinolinesHumansImipenemMicrobial Sensitivity TestsNutrientsAnti-Bacterial AgentsbedaquilineDiarylquinolinesImipenemNutrientsbedaquilineimipenemMycobacterium abscessus

Identifiers

PMID34516254
PMCPMC8597743
OpenAlexW3199848535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.