ArticleAntimicrobial agents and chemotherapy2021
Evolution of Multidrug Resistance in Plasmodium falciparum: a Longitudinal Study of Genetic Resistance Markers in the Greater Mekong Subregion.
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Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
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Who cites it
31 citing papers in PubMed, 41 citations in OpenAlex.
- Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa.Nature communications · 2025Trial
- Antibody Responses to the ConservedPathogens (Basel, Switzerland) · 2026Article
- Behavioral factors associated with artemisinin resistance: linking community treatment practices with pfkelch13 mutations in Northern Uganda.Malaria journal · 2026Article
- Double Mutations inbioRxiv : the preprint server for biology · 2026Article
- Changing genetic profiles ofAntimicrobial agents and chemotherapy · 2026Article
- Mapping the prevalence of molecular markers ofmedRxiv : the preprint server for health sciences · 2025Article
- Tolerance of Plasmodium falciparum mefloquine-resistant clinical isolates to mefloquine-piperaquine with implications for triple artemisinin-based combination therapies.Nature communications · 2025Article
- No evidence of molecular markers of piperaquine resistance in southeastern Nigeria.Malaria journal · 2025Article
- Genetic surveillance of Plasmodium falciparum populations following treatment policy revisions in the Greater Mekong Subregion.Nature communications · 2025Article
- Bridging the Gap from Molecular Surveillance to Programmatic Decisions for Malaria Control and Elimination.The American journal of tropical medicine and hygiene · 2025Review
- Artemisinin-resistant malaria.Clinical microbiology reviews · 2024Review
- Dihydroartemisinin-Piperaquine Combination in the Treatment of UncomplicatedJournal of clinical medicine · 2024Review
- Drug-induced stress mediatesMicrobiology spectrum · 2024Article
- Progress towards malaria elimination in the Greater Mekong Subregion: perspectives from the World Health Organization.Malaria journal · 2024Article
- Determinants of piperaquine-resistant malaria in South America.The Lancet. Infectious diseases · 2024Article
- Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in The Guianas: a descriptive epidemiological study.The Lancet. Infectious diseases · 2024Article
- Article
- Identification of Southeast Asian Anopheles mosquito species using MALDI-TOF mass spectrometry.PloS one · 2024Article
- Mapping the genomic landscape of multidrug resistance inScience advances · 2023Article
- Antimalarial drug discovery: progress and approaches.Nature reviews. Drug discovery · 2023Review
Corrections and comments
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Authors and funding
31 authors at 9 institutions in 7 countries.
Mallika ImwongDepartment of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.ORCID 0000-0002-8770-0573
Kanokon SuwannasinMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Suttipat SrisuthamDepartment of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
Ranitha VongpromekWorldwide Antimalarial Resistance Network, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Cholrawee PromnarateWorldwide Antimalarial Resistance Network, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Aungkana SaejengDivision of Vector-Borne Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
Aung Pyae PhyoMyanmar Oxford Clinical Research Unit, Yangon, Myanmar.ORCID 0000-0002-0383-9624
Stephane ProuxShoklo Malaria Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Mae Sot, Thailand.
Tiengkham PongvongsaSavannakhet Provincial Health Department, Savannakhet, Lao People's Democratic Republic.
Nguon CheaNational Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia.
Olivo MiottoMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Rupam TripuraMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Chau Nguyen HoangOxford University Clinical Research Unitgrid.412433.3, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Lek DysoleyNational Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia.
Nghia Ho Dang TrungOxford University Clinical Research Unitgrid.412433.3, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Thomas J PetoMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
James J CalleryMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Rob W van der PluijmMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Chanaki AmaratungaMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Mavuto MukakaMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Lorenz von SeidleinMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Mayfong MayxayCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Nguyen Thanh Thuy-NhienOxford University Clinical Research Unitgrid.412433.3, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Paul N NewtonCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Nicholas P J DayMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Elizabeth A AshleyCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Francois H NostenShoklo Malaria Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Mae Sot, Thailand.
Frank M SmithuisMyanmar Oxford Clinical Research Unit, Yangon, Myanmar.
Mehul DhordaMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Nicholas J WhiteMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Arjen M DondorpMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Mahidol University · THOxford University Clinical Research Unit · VNCambodia National Malaria Center · KHChulalongkorn University · THMahosot Hospital · LAUniversity of Oxford · GBMinistry of Public Health · THMyanmar Oxford Clinical Research Unit · MMPublic Health Department · IN
Funding
Wellcome 101148/Z/13/ZWellcome TrustWellcome Trust 106698/B/14/Z
Abstract
Increasing resistance in Plasmodium falciparum to artemisinins and their artemisinin combination therapy (ACT) partner drugs jeopardizes effective antimalarial treatment. Resistance is worst in the Greater Mekong subregion. Monitoring genetic markers of resistance can help to guide antimalarial therapy. Markers of resistance to artemisinins (
Indexed as
AntimalarialsMalaria, FalciparumATP-Binding Cassette, Sub-Family C ProteinsDrug ResistanceDrug Resistance, MultipleGenetic MarkersHumansLongitudinal StudiesPlasmodium falciparumProtozoan ProteinsAntimalarialsATP-Binding Cassette, Sub-Family C ProteinsGenetic MarkersProtozoan Proteinsgenetic resistance markersGreater Mekong subregionPlasmodium falciparum
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.