Evidence map›Paper›PMID 34516144›Full record

ArticleNano letters2021

Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles.

Xiaoqing Li, Vamsidhara Vemireddy, Qi Cai, Hejian Xiong, Peiyuan Kang, Xiuying Li, Monica Giannotta, Heather N Hayenga, Edward Pan, Shashank R Sirsi and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 98 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Xiaoqing LiDepartment of Bioengineering, University of Texas at Dallas, Richardson, Texas 75080, United States.
Vamsidhara VemireddyDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Qi CaiDepartment of Mechanical Engineering, University of Texas at Dallas, Richardson, Texas 75080, United States.
Hejian XiongDepartment of Mechanical Engineering, University of Texas at Dallas, Richardson, Texas 75080, United States.
Peiyuan KangDepartment of Mechanical Engineering, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0003-1784-865X
Xiuying LiDepartment of Mechanical Engineering, University of Texas at Dallas, Richardson, Texas 75080, United States.
Monica GiannottaFIRC Institute of Molecular Oncology Foundation (IFOM), 20139 Milan, Italy.
Heather N HayengaDepartment of Bioengineering, University of Texas at Dallas, Richardson, Texas 75080, United States.
Edward PanDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Shashank R SirsiDepartment of Bioengineering, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0002-6390-4379
Celine MateoDepartment of Physics, University of California San Diego, La Jolla, California 92093, United States.
David KleinfeldDepartment of Physics, University of California San Diego, La Jolla, California 92093, United States.
Chris GreeneSmurfit Institute of Genetics, Trinity College Dublin, Dublin 2 D02 PN40, Ireland.
Matthew CampbellSmurfit Institute of Genetics, Trinity College Dublin, Dublin 2 D02 PN40, Ireland.
Elisabetta DejanaFIRC Institute of Molecular Oncology Foundation (IFOM), 20139 Milan, Italy.
Robert BachooDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Zhenpeng QinDepartment of Bioengineering, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0003-3406-3045
The University of Texas at Dallas · USThe University of Texas Southwestern Medical Center · USIFOM · ITTrinity College Dublin · IEUniversity of California San Diego · US

Funding

TEM for UT Southwestern Electron Microscopy Core FacilityS10OD021685 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2017 to 2017
$398k
NIH HHS S10 OD021685
6 · The paper itself

Abstract

The blood-brain barrier (BBB) is highly selective and acts as the interface between the central nervous system and circulation. While the BBB is critical for maintaining brain homeostasis, it represents a formidable challenge for drug delivery. Here we synthesized gold nanoparticles (AuNPs) for targeting the tight junction specifically and demonstrated that transcranial picosecond laser stimulation of these AuNPs post intravenous injection increases the BBB permeability. The BBB permeability change can be graded by laser intensity, is entirely reversible, and involves increased paracellular diffusion. BBB modulation does not lead to significant disruption in the spontaneous vasomotion or the structure of the neurovascular unit. This strategy allows the entry of immunoglobulins and viral gene therapy vectors, as well as cargo-laden liposomes. We anticipate this nanotechnology to be useful for tissue regions that are accessible to light or fiberoptic application and to open new avenues for drug screening and therapeutic interventions in the central nervous system.

Indexed as

Metal NanoparticlesNanoparticlesBiological TransportBlood-Brain BarrierGoldLasersGoldblood−brain barriergold nanoparticletherapeutics deliverytight junction targeting

Identifiers

PMID34516144
PMCPMC8616836
OpenAlexW3200816532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.