Evidence map›Paper›PMID 34516079›Full record

ArticleACS chemical neuroscience2021

Hao Jiang, Sumit Joshi, Hui Liu, Syahir Mansor, Lin Qiu, Haiyang Zhao, Timothy Whitehead, Robert J Gropler, Gregory F Wu, Anne H Cross and 4 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Evaluation of [AJNR. American journal of neuroradiology · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. PET Quantification of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Diagnostic and Therapeutic Radiopharmaceuticals.ACS pharmacology & translational science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Hao JiangDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Sumit JoshiDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Hui LiuDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Syahir MansorDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Lin QiuDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Haiyang ZhaoDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Timothy WhiteheadDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Robert J GroplerDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Gregory F WuDepartment of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Anne H CrossDepartment of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Tammie L S BenzingerDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Kooresh I ShoghiDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Joel S PerlmutterDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.
Zhude TuDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, United States.ORCID 0000-0003-0325-835X
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Buck E. Rogers · 2018 to 2026
$12.7M
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
Neuroinflammatory Biomarkers for Nigrostriatal InjuryR01NS107281 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2019 to 2023
$3.3M
Neuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1M
NCI NIH HHS P30 CA091842NIBIB NIH HHS P41 EB025815NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS107281
6 · The paper itself

Abstract

Sphingosine-1-phosphate receptor 1 (S1PR1) is ubiquitously expressed among all tissues and plays key roles in many physiological and cellular processes. In the central nervous system (CNS), S1PR1 is expressed in different types of cells including neurons, astrocytes, and oligodendrocyte precursor cells. S1PR1 has been recognized as a novel therapeutic target in multiple sclerosis and other diseases. We previously reported a promising S1PR1-specific radioligand, [

Indexed as

Central Nervous SystemReceptors, LysosphingolipidAnimalsBrainPositron-Emission TomographyRatsSphingosine-1-Phosphate ReceptorsReceptors, LysosphingolipidS1PR1 protein, ratSphingosine-1-Phosphate Receptors[11C]CS1P1 PET imaging[3H]CS1P1 autoradiographycentral nervous systempositron emission tomographyradiopharmaceuticalsphingosine-1-phosphate receptor 1

Identifiers

PMID34516079
PMCPMC8605766
OpenAlexW3201441404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.