Evidence map›Paper›PMID 34516002›Full record

ArticleAnnals of neurology2021

Thalamic Influence on Slow Wave Slope Renormalization During Sleep.

Valeria Jaramillo, Jasmine Jendoubi, Angelina Maric, Armand Mensen, Natalie C Heyse, Aleksandra K Eberhard-Moscicka, Roland Wiest, Claudio L A Bassetti, Reto Huber

Open access · hybridAbstract read
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In one paragraph

Article in Annals of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Valeria JaramilloChildren's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich.ORCID 0000-0003-1446-8328
Jasmine JendoubiSleep-Wake-Epilepsy Center, Department of Neurology, University Hospital Bern, University of Bern, Bern, Switzerland.
Angelina MaricDepartment of Neurology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1416-6728
Armand MensenSleep-Wake-Epilepsy Center, Department of Neurology, University Hospital Bern, University of Bern, Bern, Switzerland.
Natalie C HeyseChildren's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich.
Aleksandra K Eberhard-MoscickaPerception and Eye Movement Laboratory, Departments of Neurology and Biomedical Research, University Hospital Bern, University of Bern, Bern, Switzerland.ORCID 0000-0001-5325-5152
Roland WiestDepartment of Neuroradiology, University Hospital Bern, University of Bern, Bern, Switzerland.
Claudio L A Bassetti *Sleep-Wake-Epilepsy Center, Department of Neurology, University Hospital Bern, University of Bern, Bern, Switzerland.ORCID 0000-0002-4535-0245
Reto Huber *Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich.ORCID 0000-0002-1400-9466
University of Bern · CHUniversity of Zurich · CH

Funding

Blended DEAL: CSALCRPP Sleep and Health of Universität ZürichFunding Statement: Open access funding provided by Universitat Zurich.Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 320030_153387Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung CRSII3_160803WOA Institution: Universitat Zurich
6 · The paper itself

Abstract

objectiveSlow waves are thought to mediate an overall reduction in synaptic strength during sleep. The specific contribution of the thalamus to this so-called synaptic renormalization is unknown. Thalamic stroke is associated with daytime sleepiness, along with changes to sleep electroencephalography and cognition, making it a unique "experiment of nature" to assess the relationship between sleep rhythms, synaptic renormalization, and daytime functions.

methodsSleep was studied by polysomnography and high-density electroencephalography over 17 nights in patients with thalamic (n = 12) and 15 nights in patients with extrathalamic (n = 11) stroke. Sleep electroencephalographic overnight slow wave slope changes and their relationship with subjective daytime sleepiness, cognition, and other functional tests were assessed.

resultsThalamic and extrathalamic patients did not differ in terms of age, sleep duration, or apnea-hypopnea index. Conversely, overnight slope changes were reduced in a large cluster of electrodes in thalamic compared to extrathalamic stroke patients. This reduction was related to increased daytime sleepiness. No significant differences were found in other functional tests between the 2 groups.

interpretationIn patients with thalamic stroke, a reduction in overnight slow wave slope change and increased daytime sleepiness was found. Sleep- and wake-centered mechanisms for this relationship are discussed. Overall, this study suggests a central role of the thalamus in synaptic renormalization. ANN NEUROL 2021;90:821-833.

Indexed as

AdolescentAdultAgedAged, 80 and overCognitionDisorders of Excessive SomnolenceElectroencephalographyHumansMaleMiddle AgedPolysomnographySleepStrokeThalamusYoung Adult

Identifiers

PMID34516002
PMCPMC9291607
OpenAlexW3200477643

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.