Evidence map›Paper›PMID 34515976›Full record

ArticleAdvances in therapy2021

Healthcare Resource Use in Patients with Immune-Mediated Conditions Treated with Targeted Immunomodulators During COVID-19 Pandemic: A Retrospective Claims Analysis.

Martin Bergman, Christopher D Saffore, Katherine J Kim, Pankaj A Patel, Vishvas Garg, Si Xuan, Haley B Naik

Open access · hybridAbstract read
In one paragraph

Article in Advances in therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Martin BergmanDepartment of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.
Christopher D SafforeAbbVie Inc., North Chicago, IL, USA. Christopher.Saffore@abbvie.com.
Katherine J KimAbbVie Inc., North Chicago, IL, USA.
Pankaj A PatelAbbVie Inc., North Chicago, IL, USA.
Vishvas GargAbbVie Inc., North Chicago, IL, USA.
Si XuanAbbVie Inc., North Chicago, IL, USA.
Haley B NaikDepartment of Dermatology, University of California, San Francisco, CA, USA.
AbbVie (United States) · USDrexel University · USUniversity of California, San Francisco · US

Funding

Microbial Shifts and Immune Dysregulation in Hidradenitis Suppurativa PathogenesisK23AR074531 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAIK, HALEY · 2019 to 2023
$887k
NIAMS NIH HHS K23 AR074531
6 · The paper itself

Abstract

introductionThe impact of the COVID-19 pandemic on routine medical care may result in altered healthcare resource use in patients with immune-mediated conditions. The aim of this study was to determine the impact of treatment interruptions in patients with and without COVID-19 infections who were treated with targeted immunomodulators (TIMs) in the USA.

methodsData from the IBM

resultsApproximately 25% of patients in both the COVID-19 (N = 787) and non-COVID-19 cohorts (N = 77,178) experienced interruptions in TIM therapy. In the non-COVID-19 cohort, the likelihood of being hospitalized was 20% less in patients with uninterrupted versus interrupted TIM use (aOR = 0.80, 95% CI 0.71-0.90). Patients with uninterrupted TIM use had a similar likelihood of an ED visit (aOR = 0.99, 95% CI 0.91-1.08) and respiratory outcome (aOR = 0.97, 95% CI 0.71-1.31) versus patients with interrupted TIM use. The likelihood of having an in-person outpatient visit was 87% greater in patients with uninterrupted versus interrupted TIM use (aOR = 1.87, 95% CI 1.81-1.94). Similar findings were observed in the COVID-19 cohort.

conclusionThis analysis of real-world claims data showed that uninterrupted TIM use was not associated with an increased likelihood of hospitalizations, ED visits, or negative respiratory outcomes compared to interrupted TIM use among patients with immune-mediated conditions, regardless of COVID-19 diagnosis.

Indexed as

COVID-19PandemicsCOVID-19 TestingDelivery of Health CareHumansImmunologic FactorsInsurance Claim ReviewRetrospective StudiesSARS-CoV-2Immunologic FactorsAnkylosing spondylitisAtopic dermatitisCOVID-19Crohn’s diseaseHidradenitis suppurativaPsoriasisPsoriatic arthritisRheumatoid arthritisTargeted immunomodulatorUlcerative colitis

Identifiers

PMID34515976
PMCPMC8436009
OpenAlexW3200316853

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.