Evidence map›Paper›PMID 34515954›Full record

ArticleMolecular diversity2022

Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors.

Anita Nasli Esfahani, Aida Iraji, Amir Alamir, Shahram Moradi, Mohammad Sadegh Asgari, Samanesadat Hosseini, Somayeh Mojtabavi, Ensieh Nasli-Esfahani, Mohammad Ali Faramarzi, Fatemeh Bandarian and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular diversity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Anita Nasli EsfahaniDepartment of Chemistry Tehran North Branch, Islamic Azad University, Tehran, Iran.
Aida IrajiStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Amir AlamirDepartment of Chemistry Tehran North Branch, Islamic Azad University, Tehran, Iran.
Shahram MoradiDepartment of Chemistry Tehran North Branch, Islamic Azad University, Tehran, Iran.
Mohammad Sadegh AsgariDepartment of Chemistry, Iran University of Science and Technology, Tehran, Iran.
Samanesadat HosseiniDepartment of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Somayeh MojtabaviDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Ensieh Nasli-EsfahaniDiabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Ali FaramarziDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh BandarianDiabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Bagher LarijaniEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Haleh HamedifarCinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Mir Hamed HajimiriNano Alvand Company, Tehran University of Medical Sciences, Avicenna Tech Park, 1439955991, Tehran, Iran. h.hajimiri@nanoalvand.com.
Mohammad MahdaviEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. mahdavi.chem@gmail.com.ORCID http://orcid.org/0000-0002-8007-2543
Tehran University of Medical Sciences · IRBiotechnology Research Center · IRIslamic Azad University North Tehran Branch · IRIran University of Science and Technology · IRShahid Beheshti University of Medical Sciences · IRShiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel series of phenoxymethybenzoimidazole derivatives (9a-n) were rationally designed, synthesized, and evaluated for their α-glycosidase inhibitory activity. All tested compounds displayed promising α-glycosidase inhibitory potential with IC

Indexed as

alpha-GlucosidasesGlycoside Hydrolase InhibitorsAcetamidesKineticsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipThiazolesTriazolesAcetamidesalpha-GlucosidasesGlycoside Hydrolase InhibitorsThiazolesTriazolesBenzimidazoleEnzyme inhibitionSynthesisTriazole-acetamideα-Glycosidase

Identifiers

PMID34515954
PMCPMC8436581
OpenAlexW3201581892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.