Evidence map›Paper›PMID 34515911›Full record

ArticleJournal of youth and adolescence2021

Monoaminergic Multilocus Genetic Variants Interact with Stressful Life Events in Predicting Changes in Adolescent Anxiety Symptoms: A One-year Longitudinal Study.

Cong Cao, Kexin Sun, Lili Cao, Feifei Li

Abstract read
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In one paragraph

Article in Journal of youth and adolescence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Cong CaoSchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, China. caocong@sdu.edu.cn.
Kexin SunSchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, China.
Lili CaoStudent Counseling Center, Shandong University, Jinan, China.
Feifei LiStudent Counseling Center, Shandong Medical Technician College, Tai'an, China.
Shandong University · CN

Funding

National Natural Science Foundation of China 31800936Natural Science Foundation of Shandong Province ZR2019BC111Social Science Planning Fund of Shandong Province 18DJYJ01
6 · The paper itself

Abstract

Research suggests that genetic variants linked to monoaminergic neurotransmitter function moderate the association between stress and anxiety symptoms, but examining gene-environment (G × E) interactions with individual genes limits power. As one of polygenetic approaches, the multilocus genetic profile score is derived theoretically from combining the effects of multiple candidate genes based on the "biological plausibility". Using this approach, the current study examined the interaction between monoaminergic multilocus genetic variants and stressful life events on the changes in adolescent anxiety symptoms across a one-year timespan. In a Chinese Han adolescent sample which was derived from three vocational high schools (N = 587; T1: M

Indexed as

AnxietyLife Change EventsStress, PsychologicalAdolescentChinaDepressionFemaleGene-Environment InteractionHumansLongitudinal StudiesMalePolymorphism, GeneticReceptors, Dopamine D2Receptor, Serotonin, 5-HT2CTryptophan HydroxylaseDRD2 protein, humanHTR2C protein, humanReceptors, Dopamine D2Receptor, Serotonin, 5-HT2CTPH2 protein, humanTryptophan HydroxylaseAnxiety symptomsGene-environment interactionMultilocus genetic profile scoreStressful life events

Identifiers

PMID34515911
OpenAlexW3200697635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.