Evidence map›Paper›PMID 34515905›Full record

ArticleBreast cancer research and treatment2021

Medical care disruptions during the first six months of the COVID-19 pandemic: the experience of older breast cancer survivors.

A Dilawari, K E Rentscher, W Zhai, X Zhou, T A Ahles, J Ahn, T N Bethea, J E Carroll, H J Cohen, D A Graham and 11 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03451383 (Older Breast Cancer Patients), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03451383 recruitingnot on this map

Older Breast Cancer Patients: Risk for Cognitive Decline. The Thinking and Living With Cancer (TLC) Study

TypeobservationalSponsorGeorgetown UniversityRan2010 to 2025Enrolled1,700ConditionsCancer, Breast, Age-related Cognitive Decline, Cognitive Decline
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 1 country.

A DilawariMedstar Washington Hospital Center, Washington, DC, 20007, USA.ORCID http://orcid.org/0000-0001-5706-9138
K E RentscherCousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA, USA.
W ZhaiGeorgetown-Lombardi Comprehensive Cancer Center, Georgetown University, 3300 Whitehaven Blvd, Suite 4100, Washington, DC, USA.
X ZhouGeorgetown-Lombardi Comprehensive Cancer Center, Georgetown University, 3300 Whitehaven Blvd, Suite 4100, Washington, DC, USA.
T A AhlesMemorial Sloan Kettering Cancer Center, New York, NY, USA.
J AhnCousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA, USA.
T N BetheaGeorgetown-Lombardi Comprehensive Cancer Center, Georgetown University, 3300 Whitehaven Blvd, Suite 4100, Washington, DC, USA.
J E CarrollDepartment of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
H J CohenCenter for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, USA.
D A GrahamJohn Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA.
H S L JimMoffitt Cancer Center, Tampa, FL, USA.
B McDonaldDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA.
Z M NakamuraDepartment of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
S K PatelCity of Hope National Medical Center, Los Angeles, CA, USA.
J C RootMemorial Sloan Kettering Cancer Center, New York, NY, USA.
B J SmallUniversity of South Florida, Tampa, FL, USA.
A J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA.
D TometichMoffitt Cancer Center, Tampa, FL, USA.
K Van DykDepartment of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University, Washington, DC, USA.
J S MandelblattGeorgetown-Lombardi Comprehensive Cancer Center, Georgetown University, 3300 Whitehaven Blvd, Suite 4100, Washington, DC, USA. mandelbj@georgetown.edu.
Thinking and Living with Cancer Study
University of California, Los Angeles · USGeorgetown University · USIndiana University Health · USMemorial Sloan Kettering Cancer Center · USHackensack University Medical Center · USUniversity of North Carolina at Chapel Hill · USCity Of Hope National Medical Center · USMedStar Washington Hospital Center · USMoffitt Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026
$71.5M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
UNC BIRCWH CAREER DEVELOPMENT PROGRAMK12HD001441 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOGGESS, KIM A · 2000 to 2019
$9.3M
OLDER BREAST CANCER PATIENTS: RISK FOR COGNITIVE DECLINER01CA129769 · NCI · GEORGETOWN UNIVERSITY · PI AHLES, TIM ALAN, MANDELBLATT, JEANNE · 2009 to 2020
$7.3M
Memory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9M
Bio-behavioral Research At The Intersection of Cancer and AgingR35CA197289 · NCI · GEORGETOWN UNIVERSITY · PI MANDELBLATT, JEANNE · 2015 to 2021
$6.2M
Cognition In Older Breast Cancer Survivors: Treatment Exposure, APOE, & SmokingR01CA172119 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI AHLES, TIM ALAN, HURRIA, ARTI · 2013 to 2017
$3.5M
Cognitive Aging, Alzheimers disease, and Cancer-related Cognitive DeclineR01AG068193 · NIA · GEORGETOWN UNIVERSITY · PI MANDELBLATT, JEANNE, SAYKIN, ANDREW J · 2020 to 2023
$2.8M
Accelerated biological aging in breast cancer and risk for cognitive and physical complaintsR01CA237535 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E, CARROLL, JUDITH E · 2020 to 2023
$2.1M
EPA EP-C-17-023EPA EP-D-17-023NCI NIH HHS K01 CA212056NCI NIH HHS K01CA212056NCI NIH HHS K08 CA241337NCI NIH HHS K08CA241337NCI NIH HHS P30 CA008748NCI NIH HHS P30CA008748NCI NIH HHS P30 CA051008NCI NIH HHS R01AG068193NCI NIH HHS R01 CA129769NCI NIH HHS R01CA129769NCI NIH HHS R01 CA172119NCI NIH HHS R01CA172119NCI NIH HHS R01 CA237535NCI NIH HHS R01CA237535NCI NIH HHS R35 CA197289NCI NIH HHS R35CA197289NIA NIH HHS K01 AG065485NIA NIH HHS K01AG065485NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG028716NIA NIH HHS P30AG028716NIA NIH HHS P30 AG072976NIA NIH HHS P30AG10133NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG068193NIA NIH HHS R01AG19771NIA NIH HHS R01LM01136NICHD NIH HHS K12 HD001441NIH HHS K12HD001441NIH HHS P30CA51008
6 · The paper itself

Abstract

purposeOlder cancer survivors required medical care during the COVID-19 pandemic, but there are limited data on medical care in this age group.

methodsWe evaluated care disruptions in a longitudinal cohort of non-metastatic breast cancer survivors aged 60-98 from five US regions (n = 321). Survivors completed a web-based or telephone survey from May 27, 2020 to September 11, 2020. Care disruptions included interruptions in seeing or speaking to doctors, receiving medical treatment or supportive therapies, or filling prescriptions since the pandemic began. Logistic regression models evaluated associations between care disruptions and education, medical, psychosocial, and COVID-19-related factors. Multivariate models included age, county COVID-19 death rates, comorbidity, and post-diagnosis time.

resultsThere was a high response rate (n = 262, 81.6%). Survivors were 32.2 months post-diagnosis (SD 17.5, range 4-73). Nearly half (48%) reported a medical disruption. The unadjusted odds of care disruptions were higher with each year of education (OR 1.22, 95% CI 1.08-1.37, p =  < 0.001) and increased depression by CES-D score (OR 1.04, CI 1.003-1.08, p = 0.033) while increased tangible support decreased the odds of disruptions (OR 0.99, 95% CI 0.97-0.99, p = 0.012). There was a trend between disruptions and comorbidities (unadjusted OR 1.13 per comorbidity, 95% CI 0.99-1.29, p = 0.07). Adjusting for covariates, higher education years (OR1.23, 95% CI 1.09-1.39, p = 0.001) and tangible social support (OR 0.98 95% CI 0.97-1.00, p = 0.006) remained significantly associated with having care disruptions.

conclusionOlder breast cancer survivors reported high rates of medical care disruptions during the COVID-19 pandemic and psychosocial factors were associated with care disruptions. CLINICALTRIALS. GOV IDENTIFIER: NCT03451383.

Indexed as

Breast NeoplasmsCancer SurvivorsCOVID-19AgedAged, 80 and overFemaleHumansMiddle AgedPandemicsSARS-CoV-2Breast cancerCancer survivorsCOVIDMedical care disruptionsOlder adults

Identifiers

PMID34515905
PMCPMC8436022
OpenAlexW3173113459

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.