Evidence map›Paper›PMID 34515867›Full record

ArticleEuropean journal of applied physiology2021

Sex differences in cardiovascular adaptations in recreational marathon runners.

Jacqueline A Augustine, Wesley K Lefferts, Jacob P DeBlois, Tiago V Barreira, Beth A Taylor, Kan Liu, Kevin S Heffernan

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Article in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jacqueline A AugustineKinesiology Department, School of Professional Studies, State University of New York at Cortland, Office 1149, Cortland, NY, 13045, USA. Jacqueline.augustin@cortland.edu.
Wesley K LeffertsDepartment of Exercise Science, Syracuse University, Syracuse, NY, USA.
Jacob P DeBloisDepartment of Exercise Science, Syracuse University, Syracuse, NY, USA.
Tiago V BarreiraDepartment of Exercise Science, Syracuse University, Syracuse, NY, USA.
Beth A TaylorDepartment of Kinesiology, University of Connecticut, Storrs, CT, USA.
Kan LiuDivision of Cardiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Kevin S HeffernanDepartment of Exercise Science, Syracuse University, Syracuse, NY, USA.

Funding

Phi Kappa Phi Love of Learning AwardSyracuse University School of Education Grant CompetitionSyracuse University Sydney Young Research Award
6 · The paper itself

Abstract

introductionThere are well-established sex differences in central hemodynamic and cardiac adaptations to endurance exercise; however, controversial evidence suggests that excessive endurance exercise may be related to detrimental cardiovascular adaptations in marathoners. PURPOSE: To examine left ventricle (LV) structure, LV function, 24-h central hemodynamics and ventricular-vascular coupling in male and female marathoners and recreationally active adults.

methods52 marathoners (41 ± 5 years, n = 28 female, completed 6 ± 1 marathons/3 years) and 49 recreationally active controls (42 ± 5 years, n = 25 female) participated in the study. Three-Dimensional Echocardiography (3DE) was used to measure LV mass index and LV longitudinal (LS) circumferential (CS), area (AS), and radial strain (RS). An ambulatory blood pressure (BP) cuff was used to measure 24-h central hemodynamics (BP, pulse wave velocity, PWV, wave reflection index, RIx). Hemodynamic and 3DE measures were combined to derive the ratio of arterial elastance (Ea) to ventricular elastance (Elv) as a global measure of ventricular-vascular coupling.

resultsThere were no sex or group differences in LS, CS, AS, and RS (p > 0.05). Females marathoners had similar aortic BP (116 ± 9 vs. 113 ± 1 mmHg), and PWV (5.9 ± 0.5 vs. 5.9 ± 1.1 m/s) compared to female controls but lower aSBP (116 ± 9 vs. 131 ± 10 mmHg) and PWV (5.9 ± 0.5 vs. 6.2 ± 0.5 m/s) compared to male marathoners (p < 0.05). Female marathoners had lower Ea/Elv than female controls (0.67 ± 0.20 vs. 0.93 ± 0.36) and male marathoners (0.67 ± 0.20 vs. 0.85 ± 0.42, p < 0.05).

conclusionsWomen that have completed multiple marathons do not have reduced LV function or increased aortic stiffness and may have better ventricular-vascular coupling compared to male marathoners and their female untrained counterparts.

Indexed as

Adaptation, PhysiologicalAdultBlood Pressure Monitoring, AmbulatoryEchocardiography, Three-DimensionalFemaleHemodynamicsHumansMaleMarathon RunningPulse Wave AnalysisVascular StiffnessVentricular Function, LeftHemodynamicsLeft ventricleMarathonsVascular stiffnessWomen

Identifiers

PMID34515867

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.