Evidence map›Paper›PMID 34515605›Full record

ArticleTherapeutic advances in respiratory disease

Martina Doubkova, Eva Kriegova, Simona Littnerova, Petra Schneiderova, Martina Sterclova, Vladimir Bartos, Martina Plackova, Monika Zurkova, Radka Bittenglova, Vladimira Lostaková and 8 more

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Common single nucleotide polymorphisms associated with idiopathic pulmonary fibrosis: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2024
    Pooled it
  2. Association ofInternational journal of molecular sciences · 2026
    Article
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  5. Observational
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  9. American journal of respiratory and critical care medicine · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

Martina DoubkovaDepartment of Pulmonology and Physiology, Faculty of Medicine, Masaryk University and University Hospital Brno, Jihlavská 20, 625 00 Brno, Czech Republic.ORCID 0000-0001-6536-3134
Eva KriegovaDepartment of Immunology, Faculty of Medicine and Dentistry, Palacky University in Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
Simona LittnerovaInstitute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic.
Petra SchneiderovaDepartment of Immunology, Faculty of Medicine and Dentistry, Palacky University in Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
Martina SterclovaDepartment of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic.
Vladimir BartosDepartment of Pneumology, Faculty of Medicine in Hradec Králové, Charles University, Prague, Czech Republic.
Martina PlackovaDepartment of Pneumology, Faculty of Medicine, University Hospital in Ostrava, Ostrava, Czech Republic.
Monika ZurkovaDepartment of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
Radka BittenglovaDepartment of Respiratory Diseases, Faculty of Medicine in Pilsen, Charles University and University Hospital Pilsen, Pilsen, Czech Republic.
Vladimira LostakováDepartment of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
Lenka SiskovaDepartment of Respiratory Diseases, Tomáš Baťa Regional Hospital, Zlín, Czech Republic.
Pavlina LisaDepartment of Pneumology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Hana SuldovaPulmonary Department, České Budějovice Hospital, Ceske Budejovice, Czech Republic.
Michael DoubekCentral European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Jana PsikalovaPneumoAllergology Department, Kroměříž Hospital, Kromeriz, Czech Republic.
Tomas SnizekDepartment of Respiratory Diseases, Jihlava Hospital, Jihlava, Czech Republic.
Pavlina MusilovaDepartment of Respiratory Diseases, Jihlava Hospital, Jihlava, Czech Republic.
Martina VasakovaDepartment of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic.
Charles University · CZUniversity Hospital Olomouc · CZHospital Jihlava · CZMasaryk University · CZAgricultural Research Institute Kromeriz · CZCentral European Institute of Technology · CZNemocnice České Budějovice · CZUniversity Hospital Ostrava · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe antifibrotic drugs nintedanib and pirfenidone are used for the treatment of idiopathic pulmonary fibrosis (IPF). We analysed the association of common profibrotic polymorphisms in

methods

resultsWe confirmed overexpression of the

conclusionOur real-world study showed that IPF patients with

Indexed as

DesmoplakinsIdiopathic Pulmonary FibrosisIndolesPyridonesFemaleHumansMaleMutationPilot ProjectsTreatment OutcomeDesmoplakinsIndolesnintedanibpirfenidonePyridonesantifibrotic treatmentdesmoplakinIPFmucin 5single nucleotide polymorphisms

Identifiers

PMID34515605
PMCPMC8442489
OpenAlexW3201004818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.