Evidence map›Paper›PMID 34515549›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

A functional cerebral endothelium is necessary to protect against cognitive decline.

Lianne J Trigiani, Miled Bourourou, María Lacalle-Aurioles, Clotilde Lecrux, Amy Hynes, Shoshana Spring, Darren J Fernandes, John G Sled, Frédéric Lesage, Markus Schwaninger and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Assessing cerebral capillary function and stalling using single capillary reporters in ultrasound localization microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  5. CRTC1 is a potential target to delay aging-induced cognitive deficit by protecting the integrity of the blood-brain barrier via inhibiting inflammation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  6. Article
  7. Myeloid-derived MIF drives RIPK1-mediated cerebromicrovascular endothelial cell death to exacerbate ischemic brain injury.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Lianne J TrigianiLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montréal, Canada.ORCID 0000-0002-6332-7903
Miled BourourouLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montréal, Canada.
María Lacalle-AuriolesLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montréal, Canada.
Clotilde LecruxLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montréal, Canada.
Amy HynesLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montréal, Canada.
Shoshana SpringMouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, Canada.
Darren J FernandesMouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, Canada.ORCID 0000-0002-0625-7515
John G SledMouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, Canada.
Frédéric LesageBiomedical Engineering Institute, École Polytechnique de Montréal, Montréal, Canada.
Markus SchwaningerInstitute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.ORCID 0000-0002-4510-9718
Edith HamelLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montréal, Canada.
Montreal Neurological Institute and Hospital · CAHospital for Sick Children · CAPolytechnique Montréal · CAUniversity of Lübeck · DE

Funding

CIHR MOP-126001
6 · The paper itself

Abstract

A vascular insult occurring early in disease onset may initiate cognitive decline leading to dementia, while pharmacological and lifestyle interventions can prevent this progression. Mice with a selective, tamoxifen-inducible deletion of NF-κB essential modulator (Nemo) in brain endothelial cells were studied as a model of vascular cognitive impairment. Groups included Nemo

Indexed as

BrainCerebrovascular CirculationCognitive DysfunctionEndothelium, VascularVasodilationAnimalsBlood Flow VelocityFemaleInterneuronsIntracellular Signaling Peptides and ProteinsMaleMiceMice, KnockoutSomatostatinIntracellular Signaling Peptides and ProteinsNEMO protein, mouseSomatostatinCerebral endotheliumNF-κB essential modulatorphysical exercisesimvastatinvascular cognitive impairment

Identifiers

PMID34515549
PMCPMC8721775
OpenAlexW3199328511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.