Evidence map›Paper›PMID 34515399›Full record

ArticleHead & neck2021

Whole-body hybrid positron emission tomography imaging yields clinically relevant information in the staging and restaging of sinonasal tumors.

Alexander Maurer, Christian M Meerwein, Michael B Soyka, Hannes Grünig, Stephan Skawran, Urs J Mühlematter, Michael Messerli, Cäcilia E Mader, Lars Husmann, Niels J Rupp and 2 more

Abstract read
In one paragraph

Article in Head & neck, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexander MaurerDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-6964-802X
Christian M MeerweinDepartment of Otorhinolaryngology - Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-8674-1007
Michael B SoykaDepartment of Otorhinolaryngology - Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-4179-4989
Hannes GrünigDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1188-3043
Stephan SkawranDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-2721-9726
Urs J MühlematterDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-3423-4633
Michael MesserliDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Cäcilia E MaderDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Lars HusmannDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-5878-0818
Niels J RuppDepartment of Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-7043-3456
David HolzmannDepartment of Otorhinolaryngology - Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Martin W HuellnerDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-4849-3292

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhole-body hybrid positron emission tomography (PET) imaging is increasingly used for sinonasal tumors. However, only empirical data exist on the additional, clinically relevant information derived from these techniques.

methodsThis study included 96 regionalized magnetic resonance imaging (MRI) of the sinonasal tract/neck and separate hybrid FDG-PET/CT or FDG-PET/MRI in 74 patients. Additional radiological information (ARI) obtained from each hybrid examination was analyzed and its clinically relevance was determined. Clinically relevant information (CRI) was categorized with regard to primary tumor site, regional lymph node metastases, distant metastases, second primary tumors, and non-neoplastic findings.

resultsA total of 45/96 (46.9%) hybrid PET examinations revealed ARI. CRI was found in 32/96 (33.3%) examinations and concerned the primary tumor site (6.1%), regional lymph node metastases (4.1%), distant metastases (14.3%), second primary tumors (7.3%), and non-neoplastic findings (5.1%).

conclusionsHybrid PET imaging yields additional radiological information translating into clinically relevant information in a substantial proportion of patients with sinonasal tumors.

Indexed as

Neoplasms, Second PrimaryPositron Emission Tomography Computed TomographyFluorodeoxyglucose F18HumansMagnetic Resonance ImagingNeoplasm StagingPositron-Emission TomographyRadiopharmaceuticalsSensitivity and SpecificityFluorodeoxyglucose F18Radiopharmaceuticalsclinically relevant informationfluorodeoxyglucose F18otorhinolaryngologic diseasesparanasal sinus neoplasmspositron emission tomography

Identifiers

PMID34515399
PMCPMC9293112

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.