SynthesisThe Journal of infectious diseases2022
Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review.
Synthesis in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Pooled it
- Seroprevalence of hantavirus infection in non-epidemic settings over four decades: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Orthohantavirus infections in South America: a systematic review and meta-analysis.Archives of virology · 2024Pooled it
- Land-cover, land-use and human hantavirus infection risk: a systematic review.Pathogens and global health · 2024Pooled it
- Hantavirus in Dentistry: Occupational Exposure Considerations and a Proposed Tiered Infection Prevention and Control Framework-A Narrative Review.Clinical and experimental dental research · 2026Review
- Beyond the Kidney and Lung: Cutaneous and Mucosal Clues to Human Hantavirus Disease.International journal of dermatology · 2026Review
- Characteristics and Superspreading Potential of Andes Virus Person-to-Person Transmission.Emerging infectious diseases · 2026Article
- Incidence, pathogenesis, clinical manifestations, and pharmacological management of the 2026 Andes virus outbreak.Virology journal · 2026Review
- The Changing Landscape of Hantavirus Infections: A Narrative Review of Epidemiology, Pathogenesis, and Countermeasures.Reviews in medical virology · 2026Review
- Andes hantavirus in South America: Emerging epidemiological trends, regional challenges, and lessons beyond the MV Hondius outbreak.New microbes and new infections · 2026Article
- Hanta on the Hondius - public health and bioethical perspectives of the recentNew microbes and new infections · 2026Article
- Hantavirus Cluster Linked to Cruise Ship Travel: A Comprehensive Review of a Looming Global Public Health Concern.Cureus · 2026Review
- Global threats and regional trends: Navigating the complex landscape of human orthohantavirus infections.Infectious diseases & immunity · 2026Review
- Human Orthohantavirus Infections: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Public health risk assessment of rodent-driven hantavirus spillover in Europe using a stochastic delay model.Frontiers in public health · 2026Article
- Andes hantavirus aboard an expedition cruise ship: A sentinel event for travel medicine and maritime biosurveillance.EXCLI journal · 2026Article
- Expedition cruises, island hopping, and zoonotic risk: governance and operational lessons from the MVFrontiers in medicine · 2026Article
- Hantavirus as a persistent zoonotic risk: epidemiology and current pharmacological management.Frontiers in pharmacology · 2026Review
- 2026 Cruise Ship-associated Andes Hantavirus Outbreak and Public Health Response.Public health weekly report · 2026Review
- Factors associated with laboratory confirmation of suspected hantavirus pulmonary syndrome in southern Argentina: a retrospective observational case-control study.Revista panamericana de salud publica = Pan American journal of public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundHantavirus is known to be transmitted from rodents to humans. However, some reports from Argentina and Chile have claimed that the hantavirus strain Andes virus (ANDV) can cause human-to-human transmission of the disease. The aim of this systematic review was to assess the evidence for human-to-human transmission of hantavirus.
methodsWe searched PubMed (inception to 28 February 2021), Cochrane Central, Embase, LILACS and SciELO (inception to 3 July 2020), and other sources. We included studies that assessed whether interpersonal contact with a person with laboratory-confirmed hantavirus infection led to human-to-human transmission. Two reviewers conducted screening, selection, data extraction, and risk of bias assessment.
resultsTwenty-two studies met the inclusion criteria. Meta-analysis was not possible due to heterogeneity. With the exception of 1 prospective cohort study of ANDV in Chile with serious risk of bias, evidence from comparative studies (strongest level of evidence available) does not support human-to-human transmission of hantavirus infection. Noncomparative studies with a critical risk of bias suggest that human-to-human transmission of ANDV may be possible.
conclusionsThe balance of the evidence does not support the claim of human-to-human transmission of ANDV. Well-designed cohort and case-control studies that control for co-exposure to rodents are needed to inform public health recommendations.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.