SynthesisRespiration; international review of thoracic diseases
Congenital Chylothorax of the Newborn: A Systematic Analysis of Published Cases between 1990 and 2018.
Synthesis in Respiration; international review of thoracic diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
- Diluted Etilefrine for Neonatal Chylothorax: A 96-Hour Physicochemical Stability Study.Pharmaceutics · 2026Article
- Formula for the progressive reintroduction of fat into breast milk in infants with chylothorax.JPGN reports · 2026Article
- Propranolol as Salvage Therapy for Refractory Congenital Chylous Ascites in a Preterm Neonate: A Case Report and Review of the Literature.Children (Basel, Switzerland) · 2026Article
- A Genotype-Phenotype Analysis of Four Chinese Children Carrying Distinct Pathogenic Variants in theGenes · 2026Article
- Neonatal Case of Fetal Pleural Effusion Caused by Cor Triatriatum Dexter with Postnatal Worsening of Superior Vena Cava Syndrome.Pediatric cardiology · 2026Article
- The Nutmeg Lung Pattern in a Fetus with Hypoplastic Left Heart Syndrome and Turner Syndrome.Pediatric cardiology · 2026Article
- PK/PD-guided ceftazidime-avibactam dosing for multidrug-resistantFrontiers in pharmacology · 2026Article
- Congenital chylothorax in infants: An updated scoping review.African journal of thoracic and critical care medicine · 2026Review
- Rapid spontaneous mid-trimester resolution of marked isolated bilateral fetal pleural effusions of undetermined etiology.Radiology case reports · 2025Article
- Lymphatic plastic bronchitis.World journal of pediatrics : WJP · 2025Article
- Persistent Low-Output Neonatal Chylothorax: How Long Are We Justified to Wait for Pleurodesis in Partial Responders?Pediatric pulmonology · 2025Article
- Molecular targeted treatment in infants with central conducting lymphatic anomalies.European journal of pediatrics · 2025Article
- Congenital Chylothorax and Congenital Pulmonary Airway Malformation: Case Report and Literature Review.Respirology case reports · 2025Article
- Case Report: Air-fluid point: a specific ultrasound sign for the diagnosis of hydropneumothorax in newborn infants.Frontiers in pediatrics · 2025Article
- Causes and risk factors for death in infants with congenital chylothorax.Frontiers in pediatrics · 2025Article
- Propranolol As a Treatment Option for Chylous Effusions and Chylous Ascites in Fetuses and Neonates: A Systematic Review.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Successful Treatment of Congenital Chylothorax by Early Use of Prednisolone: A Case Report.Cureus · 2024Article
- Chylothorax: pathophysiology, diagnosis, and management-a comprehensive review.Journal of thoracic disease · 2024Review
- Immunological characterization of pleural effusions in pediatric patients.Frontiers in immunology · 2024Article
- Risk Factors of Chylothorax After Congenital Heart Surgery in Infants: A Single-Centre Retrospective Study.Therapeutics and clinical risk management · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCongenital chylothorax (CCT) of the newborn is a rare entity but the most common cause of pleural effusion in this age-group. We aimed to find the optimal treatment strategy. MATERIAL AND
methodsA PubMed search was performed according to the PRISMA criteria. All cases were analyzed according to prenatal, perinatal, and postnatal treatment modalities and follow-ups.
resultsWe identified 753 cases from 157 studies published between 1990 and 2018. The all-cause mortality rate was 28%. Prematurity was present in 71%, male gender dominated 57%, mean gestational age was 34 weeks, and birth weight was 2,654 g. Seventy-nine percent of newborns had bilateral CCT, the most common associated congenital anomalies with CCT were pulmonary lymphangiectasia and pulmonary hypoplasia, and the most common chromosomal aberrations were Down, Noonan, and Turner syndromes, respectively. Mechanical ventilation was reported in 381 cases for mean 17 (range 1-120) days; pleural punctuations and drainages were performed in 32% and 64%, respectively. Forty-four percent received total parenteral nutrition (TPN) for mean 21 days, 46% medium-chain triglyceride (MCT) diet for mean 37 days, 20% octreotide, and 3% somatostatin; chemical pleurodesis was performed in 116 cases, and surgery was reported in 48 cases with a success rate of 69%. In 462 cases (68%), complete restitution was reported; in 34 of 44 cases (77%), intrauterine intervention was carried out.
conclusionRespiratory support, pleural drainages, TPN, and MCT diet as octreotide remain to be the cornerstones of CCT management. Pleurodesis with OK-432 done prenatally and povidone-iodine postnatally might be discussed for use in life-threatening CCT.
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