Evidence map›Paper›PMID 34515199›Full record

ArticleObesity facts2021

Relation of Maximum Lifetime Body Mass Index with Age at Hemodialysis Initiation and Vascular Complications in Japan.

Akira Onozaki, Daiji Nagayama, Nakanobu Azuma, Keita Sugai, Etsuko Shitara, Takehiko Sakai, Motoyuki Masai, Kohji Shirai, Ichiro Tatsuno

Open access · goldAbstract read
In one paragraph

Article in Obesity facts, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Akira OnozakiInternal Medicine, Tokatsu Clinic Hospital, Chiba, Japan.
Daiji NagayamaInternal Medicine, Nagayama Clinic, Tochigi, Japan.
Nakanobu AzumaInternal Medicine, Tokatsu Clinic Hospital, Chiba, Japan.
Keita SugaiNutrition Management Division, Mihama Hospital, Chiba, Japan.
Etsuko ShitaraNutrition Management Division, Mihama Hospital, Chiba, Japan.
Takehiko SakaiDepartment of Urology, Mihama Hospital, Chiba, Japan.
Motoyuki MasaiDepartment of Urology, Mihama Hospital, Chiba, Japan.
Kohji ShiraiInternal Medicine, Mihama Hospital, Chiba, Japan.
Ichiro TatsunoCenter of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Tokatsu Hospital · JPTomitahama Hospital · JPChiba Prefectural University of Health Sciences · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to investigate the association of the maximum lifetime body mass index (max BMI) with hemodialysis initiation and comorbidities in Japanese hemodialysis patients.

methodsIn a retrospective cross-sectional study on 724 hemodialysis patients, max BMI, age at hemodialysis initiation, and comorbidities including sleep apnea syndrome, cerebro-cardiovascular diseases, and proliferative diabetic retinopathy (PDR) were analyzed. Early hemodialysis initiation was defined as age <50 years.

resultDiabetes patients showed a higher max BMI and prevalence of atherosclerotic diseases than nondiabetes patients, despite almost the same age at hemodialysis initiation. Patients with early hemodialysis initiation showed higher male ratio, prevalence of PDR, and max BMI than those with later initiation, despite almost equal prevalence of diabetes. Receiver-operating characteristic curve analysis determined a max BMI of 28.4 kg/m2 as a reliable cutoff value for predicting early hemodialysis initiation, and this parameter was identified as an independent predictor of early hemodialysis initiation using bivariate logistic regression analysis. Vitrectomy for PDR also tended to contribute independently to early hemodialysis initiation.

conclusionA high max BMI contributed to early hemodialysis initiation independent of diabetes. Furthermore, PDR was associated with a high max BMI and early hemodialysis initiation. These results suggest that weight reduction in young chronic kidney disease patients with obesity may prevent hemodialysis and blindness.

Indexed as

Cardiovascular DiseasesBody Mass IndexCross-Sectional StudiesHumansJapanMaleMiddle AgedRenal DialysisRetrospective StudiesRisk FactorsDiabetic retinopathyEnd-stage renal diseaseHemodialysis initiationMaximum lifetime body mass indexObesity management

Identifiers

PMID34515199
PMCPMC8546452
OpenAlexW3195734961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.